C₂₉H₂₉N₅O₃

Base Information

Chemical Name:C₂₉H₂₉N₅O₃
CAS No.:1332640-28-4
Molecular Formula:C₂₉H₂₉N₅O₃
Molecular Weight:495.581
Hs Code.:

C<sub>29</sub>H<sub>29</sub>N<sub>5</sub>O<sub>3</sub>

Synonyms:

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Chemical Property of C₂₉H₂₉N₅O₃

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Technology Process of C₂₉H₂₉N₅O₃

There total 28 articles about C₂₉H₂₉N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187039-57-2,335280-19-8
(2S,3S)-1-(tert-butoxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

: 1332640-28-4
C₂₉H₂₉N₅O₃

Guidance literature:: Multi-step reaction with 20 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 90 °C

2.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

3.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C

4.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

5.1: triethylamine / 12 h

6.1: thionyl chloride / dichloromethane / 1 h / -78 °C

6.2: 1 h / -78 °C

7.1: / acetonitrile / 16 h / 20 °C

8.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

9.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

11.1: dmap / dichloromethane / 3 h / 0 °C

12.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

13.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

14.1: triethylamine / diethyl ether; tetrahydrofuran / 20 °C

14.2: 1 h / -30 °C

14.3: 19 h / -30 - 20 °C

15.1: hydrogen bromide / 1,4-dioxane / 0.5 h / 0 - 20 °C

16.1: ethanol / 19 h / Reflux

17.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 3 h / Reflux

18.1: hydrogen / palladium 10% on activated carbon / methanol

19.1: HATU / 1-methyl-pyrrolidin-2-one

20.1: trifluoroacetic acid / dichloromethane

With 1H-imidazole; dmap; sodium periodate; lithium borohydride; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 184046-78-4
(2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate

: 1332640-28-4
C₂₉H₂₉N₅O₃

Guidance literature:: Multi-step reaction with 19 steps

1.1: 1H-imidazole / dichloromethane / 6 h / 0 - 20 °C

2.1: lithium borohydride / tetrahydrofuran / 3 h / 0 - 20 °C

3.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

4.1: triethylamine / 12 h

5.1: thionyl chloride / dichloromethane / 1 h / -78 °C

5.2: 1 h / -78 °C

6.1: / acetonitrile / 16 h / 20 °C

7.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

8.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

10.1: dmap / dichloromethane / 3 h / 0 °C

11.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

12.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

13.1: triethylamine / diethyl ether; tetrahydrofuran / 20 °C

13.2: 1 h / -30 °C

13.3: 19 h / -30 - 20 °C

14.1: hydrogen bromide / 1,4-dioxane / 0.5 h / 0 - 20 °C

15.1: ethanol / 19 h / Reflux

16.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 3 h / Reflux

17.1: hydrogen / palladium 10% on activated carbon / methanol

18.1: HATU / 1-methyl-pyrrolidin-2-one

19.1: trifluoroacetic acid / dichloromethane

With 1H-imidazole; dmap; sodium periodate; lithium borohydride; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 156129-73-6
tert-butyl (2R,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1332640-28-4
C₂₉H₂₉N₅O₃

Guidance literature:: Multi-step reaction with 17 steps

1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 2 h / 0 - 20 °C

2.1: triethylamine / 12 h

3.1: thionyl chloride / dichloromethane / 1 h / -78 °C

3.2: 1 h / -78 °C

4.1: / acetonitrile / 16 h / 20 °C

5.1: hydrogen / ethanol / 1.5 h / 2585.81 Torr

6.1: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 20 - 45 °C

8.1: dmap / dichloromethane / 3 h / 0 °C

9.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

10.1: sodium periodate / ruthenium(III) trichloride hydrate / 1-methyl-pyrrolidin-2-one; tetrachloromethane; acetonitrile; water / 3.83 h

11.1: triethylamine / diethyl ether; tetrahydrofuran / 20 °C

11.2: 1 h / -30 °C

11.3: 19 h / -30 - 20 °C

12.1: hydrogen bromide / 1,4-dioxane / 0.5 h / 0 - 20 °C

13.1: ethanol / 19 h / Reflux

14.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 3 h / Reflux

15.1: hydrogen / palladium 10% on activated carbon / methanol

16.1: HATU / 1-methyl-pyrrolidin-2-one

17.1: trifluoroacetic acid / dichloromethane

With dmap; sodium periodate; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen bromide; hydrogen; sulfur trioxide pyridine complex; sodium hydride; potassium carbonate; triethylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; ruthenium(III) trichloride hydrate; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; tetrachloromethane; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; acetonitrile;