<2-<(4-bromo-2-fluorophenyl)methyl>-3-cyano-1,1-dioxo-2,3-dihydrobenzisothiazol-3-yl>-α-cyanoacetic acid ethyl ester

Base Information

Chemical Name:<2-<(4-bromo-2-fluorophenyl)methyl>-3-cyano-1,1-dioxo-2,3-dihydrobenzisothiazol-3-yl>-α-cyanoacetic acid ethyl ester
CAS No.:145020-72-0
Molecular Formula:C₂₀H₁₅BrFN₃O₄S
Molecular Weight:492.325
Hs Code.:

<2-<(4-bromo-2-fluorophenyl)methyl>-3-cyano-1,1-dioxo-2,3-dihydrobenz<d>isothiazol-3-yl>-α-cyanoacetic acid ethyl ester

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Chemical Property of <2-<(4-bromo-2-fluorophenyl)methyl>-3-cyano-1,1-dioxo-2,3-dihydrobenzisothiazol-3-yl>-α-cyanoacetic acid ethyl ester

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Technology Process of <2-<(4-bromo-2-fluorophenyl)methyl>-3-cyano-1,1-dioxo-2,3-dihydrobenzisothiazol-3-yl>-α-cyanoacetic acid ethyl ester

There total 5 articles about <2-<(4-bromo-2-fluorophenyl)methyl>-3-cyano-1,1-dioxo-2,3-dihydrobenzisothiazol-3-yl>-α-cyanoacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 151-50-8
potassium cyanide

: 127516-75-0
<2,3-dihydro-2-<(4-bromo-2-fluorophenyl)methyl>benzisothiazol-3-ylidene>-α-cyanoacetic acid ethyl ester 1,1-dioxide

: 145020-72-0
<2-<(4-bromo-2-fluorophenyl)methyl>-3-cyano-1,1-dioxo-2,3-dihydrobenzisothiazol-3-yl>-α-cyanoacetic acid ethyl ester

Guidance literature:: In dimethyl sulfoxide; for 1.41667h; Ambient temperature;
DOI:10.1021/jm00102a016

Reference yield:

: 128-44-9
saccharin sodium salt

: 145020-72-0
<2-<(4-bromo-2-fluorophenyl)methyl>-3-cyano-1,1-dioxo-2,3-dihydrobenzisothiazol-3-yl>-α-cyanoacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / dimethylformamide / 1 h / 100 °C

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

3: 73 percent / acetic anhydride / 0.83 h / Heating

4: 68 percent / dimethylsulfoxide / 1.42 h / Ambient temperature

With potassium tert-butylate; acetic anhydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00102a016

Reference yield:

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 145020-72-0
<2-<(4-bromo-2-fluorophenyl)methyl>-3-cyano-1,1-dioxo-2,3-dihydrobenzisothiazol-3-yl>-α-cyanoacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / dimethylformamide / 1 h / 100 °C

2: 1.) potassium tert-butoxide / 1.) THF, 60 deg C, 45 min, 2.) THF, reflux, 3 h

3: 73 percent / acetic anhydride / 0.83 h / Heating

4: 68 percent / dimethylsulfoxide / 1.42 h / Ambient temperature

With potassium tert-butylate; acetic anhydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00102a016