3'-amino-3'-deoxy-3'-[[2'-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

Base Information

• Chemical Name: 3'-amino-3'-deoxy-3'-[[2'-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate
• CAS No.: 833447-57-7
• Molecular Formula: C₆₁H₅₉N₇O₁₁
• Molecular Weight: 1067.17

Synonyms:

Chemical Property of 3'-amino-3'-deoxy-3'-[[2'-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 3'-amino-3'-deoxy-3'-[[2'-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate

There total 1 articles about 3'-amino-3'-deoxy-3'-[[2'-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

succinic acid anhydride (108-30-5) + 3'-amino-3'-deoxy-3'-[[2-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N6,N6-dimethyladenosine → 3'-amino-3'-deoxy-3'-[[2'-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N6,N6-dimethyladenosine 2'-O-succinate (833447-57-7)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 24h;

DOI:10.1016/j.tet.2004.10.023

Reference yield:

4-acetyl-5'-O-[benzhydroxybis(trimethylsiloxy)silyl]-2'-O-[bis(2-acetoxyethoxy)methyl]cytidine-3'-(methyl-N,N-diisopropyl)phosphoramidite + 3'-amino-3'-deoxy-3'-[[2'-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N6,N6-dimethyladenosine 2'-O-succinate (833447-57-7) → cytidylyl-(3'-5')-3'-amino-3'-deoxy-3'-([2-15NH2]-L-phenylalanyl)-N6,N6-dimethyladenosine

Guidance literature:

3'-amino-3'-deoxy-3'-[[2'-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate; With pyridine; dmap; LCAA-polystyrene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; for 26h;

4-acetyl-5'-O-[benzhydroxybis(trimethylsiloxy)silyl]-2'-O-[bis(2-acetoxyethoxy)methyl]cytidine-3'-(methyl-N,N-diisopropyl)phosphoramidite;

DOI:10.1016/j.tet.2004.10.023

Reference yield:

[3-15N,4-15NH2]-4-acetyl-5'-O-[benzhydroxy-bis(trimethylsiloxy)silyl]-2'-O-[bis(2-acetoxyethoxy)methyl]cytidine-3'-(methyl-N,N-diisopropyl)phosphoramidite + 3'-amino-3'-deoxy-3'-[[2'-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N6,N6-dimethyladenosine 2'-O-succinate (833447-57-7) → [3-15N,4-15NH2]cytidylyl-(3'-5')-3'-amino-3'-deoxy-3'-([2-(15)NH]-phenylalanyl)-N6,N6-dimethyladenosine

Guidance literature:

3'-amino-3'-deoxy-3'-[[2'-15NH]-N-(9-fluorenylmethoxycarbonyl)-L-phenylalanyl]-5'-O-(p,p'-dimethoxytrityl)-N⁶,N⁶-dimethyladenosine 2'-O-succinate; With pyridine; dmap; LCAA-polystyrene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; for 26h;

[3-15N,4-15NH₂]-4-acetyl-5'-O-[benzhydroxy-bis(trimethylsiloxy)silyl]-2'-O-[bis(2-acetoxyethoxy)methyl]cytidine-3'-(methyl-N,N-diisopropyl)phosphoramidite;

DOI:10.1016/j.tet.2004.10.023

upstream raw materials:

succinic acid anhydride

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