(R)-ethyl 3-amino-3-(3-chloro-5-(1-cyanocyclobutyl)phenyl)propanoate

Base Information

Chemical Name:(R)-ethyl 3-amino-3-(3-chloro-5-(1-cyanocyclobutyl)phenyl)propanoate
CAS No.:1541199-24-9
Molecular Formula:C₁₆H₁₉ClN₂O₂
Molecular Weight:306.792
Hs Code.:

Synonyms:

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Chemical Property of (R)-ethyl 3-amino-3-(3-chloro-5-(1-cyanocyclobutyl)phenyl)propanoate

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Technology Process of (R)-ethyl 3-amino-3-(3-chloro-5-(1-cyanocyclobutyl)phenyl)propanoate

There total 10 articles about (R)-ethyl 3-amino-3-(3-chloro-5-(1-cyanocyclobutyl)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3721-95-7
Cyclobutanecarboxylic acid

: 1541199-24-9
(R)-ethyl 3-amino-3-(3-chloro-5-(1-cyanocyclobutyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 8 h / 70 °C

2.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.25 h / 0 - 25 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: water; sodium hydroxide / methanol / 3 h / 80 °C

4.1: tert-butyl chloroformate; triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

5.1: trifluoroacetic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: toluene-4-sulfonic acid / acetone / 14 h / 20 °C / Inert atmosphere

7.1: ammonium acetate / ethanol / 7 h / 80 °C

8.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 120 h / 20 °C / pH 8.25 / Enzymatic reaction

8.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; sulfuric acid; ammonium acetate; water; toluene-4-sulfonic acid; tert-butyl chloroformate; triethylamine; N-cyclohexyl-cyclohexanamine; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; acetone; toluene;

Reference yield:

: 765-85-5
methyl cyclobutanecarboxylate

: 1541199-24-9
(R)-ethyl 3-amino-3-(3-chloro-5-(1-cyanocyclobutyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium; N-cyclohexyl-cyclohexanamine / hexane; toluene / 0.25 h / 0 - 25 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

2.1: water; sodium hydroxide / methanol / 3 h / 80 °C

3.1: tert-butyl chloroformate; triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

4.1: trifluoroacetic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

5.1: toluene-4-sulfonic acid / acetone / 14 h / 20 °C / Inert atmosphere

6.1: ammonium acetate / ethanol / 7 h / 80 °C

7.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 120 h / 20 °C / pH 8.25 / Enzymatic reaction

7.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; n-butyllithium; Amano Lipase PS; ammonium acetate; water; toluene-4-sulfonic acid; tert-butyl chloroformate; triethylamine; N-cyclohexyl-cyclohexanamine; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; water; acetone; toluene;

Reference yield:

: 1541198-23-5
C₁₄H₁₅ClO₄

: 1541199-24-9
(R)-ethyl 3-amino-3-(3-chloro-5-(1-cyanocyclobutyl)phenyl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert-butyl chloroformate; triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: trifluoroacetic anhydride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / acetone / 14 h / 20 °C / Inert atmosphere

4.1: ammonium acetate / ethanol / 7 h / 80 °C

5.1: potassium dihydrogenphosphate; Amano Lipase PS; sodium hydroxide / water / 120 h / 20 °C / pH 8.25 / Enzymatic reaction

5.2: 0.25 h / 20 °C

With potassium dihydrogenphosphate; Amano Lipase PS; ammonium acetate; toluene-4-sulfonic acid; tert-butyl chloroformate; triethylamine; trifluoroacetic anhydride; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; acetone;