METHYL CYCLOBUTANECARBOXYLATE

Base Information

• Chemical Name: METHYL CYCLOBUTANECARBOXYLATE
• CAS No.: 765-85-5
• Molecular Formula: C6H10O2
• Molecular Weight: 114.144
• Hs Code.: 29162000
• Mol file: 765-85-5.mol

Synonyms:Methylcyclobutanecarboxylate;

Chemical Property of METHYL CYCLOBUTANECARBOXYLATE

Chemical Property:

• Appearance/Colour: Clear colorless liquid
• Vapor Pressure: 6.64mmHg at 25°C
• Refractive Index: 1.428-1.43
• Boiling Point: 138.7 °C at 760 mmHg
• Flash Point: 30.1 °C
• PSA: 26.30000
• Density: 1.051 g/cm³
• LogP: 0.95950

Purity/Quality:

99% ^*data from raw suppliers

Methyl Cyclobutanecarboxylate ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL CYCLOBUTANECARBOXYLATE

There total 2 articles about METHYL CYCLOBUTANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

methyl 2,5-dibromovalerate (50995-48-7) → methyl valerate (624-24-8) + 5-bromovaleric acid methyl ester (5454-83-1) + methyl cyclobutanecarboxylate (765-85-5)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; Yields of byproduct given; electrolysis;

Reference yield:

2-chlorocyclopentanone (694-28-0) → methyl cyclobutanecarboxylate (765-85-5) + 2-(cyclobutylcarbonyl) cyclopentanone (127865-06-9) + cyclopentanone (120-92-3)

Guidance literature:

With oxygen; tetraethylammonium perchlorate; In N,N-dimethyl-formamide; at 20 ℃; Mechanism; other substituted cycloketones and alkyl carboxylates; electrolysis;

Reference yield: 90.0%

methyl cyclobutanecarboxylate (765-85-5) + tert-butyl 2-(4-((4-chlorobenzyl)oxy)phenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate → methyl 3-(2-(4-((4-chlorobenzyl)oxy)phenyl)-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)cyclobutanecarboxylate

Guidance literature:

methyl cyclobutanecarboxylate; tert-butyl 2-(4-((4-chlorobenzyl)oxy)phenyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate; With PYRIMIDINE; In tetrahydrofuran; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; for 5h;

upstream raw materials:

2-chlorocyclopentanone

methyl 2,5-dibromovalerate

Downstream raw materials:

cyclobutyldiphenylcarbinol

Bis-(p-dimethylaminophenyl)-cyclobutyliden-methan

Cyclobutyl-di-naphthalen-2-yl-methanol

methyl 1-methylcyclobutanecarboxylate

Refernces

• 1、 Giomini, Claudio,Inesi, Achille,Zeuli, Errico. "ELECTROCHEMICALLY-INITIATED RING CLOSURE: REDUCTION OF α,γ- AND α,δ-DIBROMOESTERS". . p. 2401 - 2416. Retrieved 2007/10/02.