N_α-propanoyl>ACHPA>Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Base Information

Chemical Name:N_α-propanoyl>ACHPA>Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide
CAS No.:136658-79-2
Molecular Formula:C₄₃H₆₇N₇O₇
Molecular Weight:794.048
Hs Code.:

N<sub>α</sub>-<N-<3-<(4S,5S)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyl-5-oxazolidinyl>propanoyl>ACHPA>Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N_α-propanoyl>ACHPA>Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

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Technology Process of N_α-propanoyl>ACHPA>Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

There total 12 articles about N_α-propanoyl>ACHPA>Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 136735-33-6
H-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide dihydrochloride

: 136630-82-5
(4S,5S)-4-benzyl-5-(2-carboxyethyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 136658-79-2,136735-31-4
N_α-propanoyl>ACHPA>Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 14h; Ambient temperature;
DOI:10.1021/jm00115a016

Reference yield: 61.0%

: 136735-33-6
H-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide dihydrochloride

: 136630-83-6
(4S,5R)-4-benzyl-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-5-propanoic acid

: 136658-79-2,136735-31-4
N_α-propanoyl>ACHPA>Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 14h; Ambient temperature;
DOI:10.1021/jm00115a016

Reference yield:

: 101669-80-1
methyl (3S,4S)-N-tert-butoxycarbonyl-4-amino-3-hydroxy-5-phenylpentanoate

: 136658-79-2,136735-31-4
N_α-propanoyl>ACHPA>Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / p-toluenesulfonic acid / CH₂Cl₂ / 14 h

2: Dibal / tetrahydrofuran; toluene / 1 h / 0 °C

3: triethylamine / CH₂Cl₂ / 4 h / 0 °C

4: dimethylsulfoxide / 24 h / 50 °C

5: 85 percent / 30percent aq. KOH / methanol / 8 h / Heating

6: 64 percent / N-methylmorpholine (NMM), 1-hydroxybenzotriazole (HOBT), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCI) / dimethylformamide / 14 h / Ambient temperature

With 4-methyl-morpholine; potassium hydroxide; diisobutylaluminium hydride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00115a016