(S)-2-{Methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-(2-nitro-benzenesulfonyl)-amino]-butyryl}-amino)-butyryl]-amino}-3-phenyl-propionic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-{Methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-(2-nitro-benzenesulfonyl)-amino]-butyryl}-amino)-butyryl]-amino}-3-phenyl-propionic acid tert-butyl ester
CAS No.:871732-87-5
Molecular Formula:C₃₂H₄₆N₄O₈S
Molecular Weight:646.805
Hs Code.:

(S)-2-{Methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-(2-nitro-benzenesulfonyl)-amino]-butyryl}-amino)-butyryl]-amino}-3-phenyl-propionic acid tert-butyl ester

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Chemical Property of (S)-2-{Methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-(2-nitro-benzenesulfonyl)-amino]-butyryl}-amino)-butyryl]-amino}-3-phenyl-propionic acid tert-butyl ester

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Technology Process of (S)-2-{Methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-(2-nitro-benzenesulfonyl)-amino]-butyryl}-amino)-butyryl]-amino}-3-phenyl-propionic acid tert-butyl ester

There total 13 articles about (S)-2-{Methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-(2-nitro-benzenesulfonyl)-amino]-butyryl}-amino)-butyryl]-amino}-3-phenyl-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 845777-61-9
(2S)-3-methyl-2-(o-nitro-benzenesulfonyl-methyl-amino)-butyryl chloride

: 845777-63-1
(S)-2-[Methyl-((S)-3-methyl-2-methylamino-butyryl)-amino]-3-phenyl-propionic acid tert-butyl ester

: 871732-87-5
(S)-2-{Methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-(2-nitro-benzenesulfonyl)-amino]-butyryl}-amino)-butyryl]-amino}-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2005.09.040

Reference yield:

: 845777-58-4
N-(o-nitrobenzenesulfonyl)-N-methyl-L-valine tert-butyl ester

: 871732-87-5
(S)-2-{Methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-(2-nitro-benzenesulfonyl)-amino]-butyryl}-amino)-butyryl]-amino}-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: TFA / CH₂Cl₂ / 0 °C

2: oxalyl chloride; DMF / CH₂Cl₂ / 0 °C

3: 92.7 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

4: LiOH*H₂O; mercaptoacetic acid / dimethylformamide / 2 h / 0 - 20 °C

5: 5.60 g / triethylamine / CH₂Cl₂ / 0 - 20 °C

With lithium hydroxide; oxalyl dichloride; mercaptoacetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.09.040

Reference yield:

: 13211-31-9
tert-butyl L-valinate

: 871732-87-5
(S)-2-{Methyl-[(S)-3-methyl-2-(methyl-{(S)-3-methyl-2-[methyl-(2-nitro-benzenesulfonyl)-amino]-butyryl}-amino)-butyryl]-amino}-3-phenyl-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 91 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

2: 77 percent / potassium carbonate / dimethylformamide / 0 - 20 °C

3: TFA / CH₂Cl₂ / 0 °C

4: oxalyl chloride; DMF / CH₂Cl₂ / 0 °C

5: 92.7 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

6: LiOH*H₂O; mercaptoacetic acid / dimethylformamide / 2 h / 0 - 20 °C

7: 5.60 g / triethylamine / CH₂Cl₂ / 0 - 20 °C

With lithium hydroxide; oxalyl dichloride; potassium carbonate; mercaptoacetic acid; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2005.09.040