(2S,5S,6R,11S,14S,15R)-6-(2-Amino-propionylsulfanylmethyl)-15-(2-benzyloxycarbonylamino-acetylsulfanylmethyl)-5,14-bis-(2-methoxy-phenoxymethyl)-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester; hydrobromide

Base Information

Chemical Name:(2S,5S,6R,11S,14S,15R)-6-(2-Amino-propionylsulfanylmethyl)-15-(2-benzyloxycarbonylamino-acetylsulfanylmethyl)-5,14-bis-(2-methoxy-phenoxymethyl)-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester; hydrobromide
CAS No.:132757-33-6
Molecular Formula:BrH*C₄₇H₆₂N₂O₁₈S₂
Molecular Weight:1088.06
Hs Code.:

(2S,5S,6R,11S,14S,15R)-6-(2-Amino-propionylsulfanylmethyl)-15-(2-benzyloxycarbonylamino-acetylsulfanylmethyl)-5,14-bis-(2-methoxy-phenoxymethyl)-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester; hydrobromide

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Chemical Property of (2S,5S,6R,11S,14S,15R)-6-(2-Amino-propionylsulfanylmethyl)-15-(2-benzyloxycarbonylamino-acetylsulfanylmethyl)-5,14-bis-(2-methoxy-phenoxymethyl)-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester; hydrobromide

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Technology Process of (2S,5S,6R,11S,14S,15R)-6-(2-Amino-propionylsulfanylmethyl)-15-(2-benzyloxycarbonylamino-acetylsulfanylmethyl)-5,14-bis-(2-methoxy-phenoxymethyl)-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester; hydrobromide

There total 14 articles about (2S,5S,6R,11S,14S,15R)-6-(2-Amino-propionylsulfanylmethyl)-15-(2-benzyloxycarbonylamino-acetylsulfanylmethyl)-5,14-bis-(2-methoxy-phenoxymethyl)-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester; hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-1-[(2S,5S,6S,11S,14S,15S)-6,15-Bis-benzyloxymethyl-11-((R)-1,2-dihydroxy-ethyl)-5,14-bis-hydroxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-yl]-ethane-1,2-diol

: 132757-33-6
(2S,5S,6R,11S,14S,15R)-6-(2-Amino-propionylsulfanylmethyl)-15-(2-benzyloxycarbonylamino-acetylsulfanylmethyl)-5,14-bis-(2-methoxy-phenoxymethyl)-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester; hydrobromide

Guidance literature:: Multi-step reaction with 13 steps

1: TsOH

2: pyridine

3: NaH / dimethylsulfoxide

4: 1N HCl / tetrahydrofuran

5: NaIO₄, aq. NaHCO₃ / tetrahydrofuran

6: PDC / dimethylformamide

7: diethyl ether

8: H₂ / Pd/C / methanol

9: pyridine

10: tetrahydrofuran

11: K₂CO₃ / methanol

12: DEPC, TEA / dimethylformamide

13: pyridine / CH₂Cl₂

With pyridine; hydrogenchloride; sodium periodate; dipyridinium dichromate; TEA; hydrogen; sodium hydride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; diethyl dicarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)98026-2

Reference yield:

: [(2S,3S,8S,11S,12S,17S)-3,12-Bis-benzyloxymethyl-8,17-bis-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-11-hydroxymethyl-1,4,7,10,13,16-hexaoxa-cyclooctadec-2-yl]-methanol

: 132757-33-6
(2S,5S,6R,11S,14S,15R)-6-(2-Amino-propionylsulfanylmethyl)-15-(2-benzyloxycarbonylamino-acetylsulfanylmethyl)-5,14-bis-(2-methoxy-phenoxymethyl)-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester; hydrobromide

Guidance literature:: Multi-step reaction with 12 steps

1: pyridine

2: NaH / dimethylsulfoxide

3: 1N HCl / tetrahydrofuran

4: NaIO₄, aq. NaHCO₃ / tetrahydrofuran

5: PDC / dimethylformamide

6: diethyl ether

7: H₂ / Pd/C / methanol

8: pyridine

9: tetrahydrofuran

10: K₂CO₃ / methanol

11: DEPC, TEA / dimethylformamide

12: pyridine / CH₂Cl₂

With pyridine; hydrogenchloride; sodium periodate; dipyridinium dichromate; TEA; hydrogen; sodium hydride; sodium hydrogencarbonate; potassium carbonate; diethyl dicarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)98026-2

Reference yield:

: (2S,5S,6S,11S,14S,15S)-6,15-Bis-benzyloxymethyl-5,14-bis-(2-methoxy-phenoxymethyl)-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarbaldehyde

: 132757-33-6
(2S,5S,6R,11S,14S,15R)-6-(2-Amino-propionylsulfanylmethyl)-15-(2-benzyloxycarbonylamino-acetylsulfanylmethyl)-5,14-bis-(2-methoxy-phenoxymethyl)-1,4,7,10,13,16-hexaoxa-cyclooctadecane-2,11-dicarboxylic acid dimethyl ester; hydrobromide

Guidance literature:: Multi-step reaction with 8 steps

1: PDC / dimethylformamide

2: diethyl ether

3: H₂ / Pd/C / methanol

4: pyridine

5: tetrahydrofuran

6: K₂CO₃ / methanol

7: DEPC, TEA / dimethylformamide

8: pyridine / CH₂Cl₂

With pyridine; dipyridinium dichromate; TEA; hydrogen; potassium carbonate; diethyl dicarbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)98026-2