Naftopidil, (R)-

Base Information

Chemical Name:Naftopidil, (R)-
CAS No.:127931-15-1
Molecular Formula:C24H28N2O3
Molecular Weight:392.49100
Hs Code.:
UNII:PG1LF4426M
Nikkaji Number:J277.692H
Wikidata:Q27286531
Pharos Ligand ID:7QBLPK3Z1X8A
ChEMBL ID:CHEMBL1446968
Mol file:127931-15-1.mol

Synonyms:Naftopidil, (R)-;(-)-Naftopidil;R-(-)-Naftopidil;Naftopidil, (-)-;R-(+)-NAFTOPIDIL;127931-15-1;UNII-PG1LF4426M;PG1LF4426M;(2R)-1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol;1-Piperazineethanol, 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-, (alphaR)-;1-Piperazineethanol, 4-(2-methoxyphenyl)-alpha-((1-naphthalenyloxy)methyl)-, (R)-;(R)-naftopidil;Tocris-0597;Lopac-N-158;CHEMBL1446968;SCHEMBL12397621;NCGC00015718-01;NCGC00015718-02;NCGC00015718-03;NCGC00015718-07;NCGC00016882-01;NCGC00024672-01;PD132421;CAS-57149-08-3;Q27286531;1-PIPERAZINEETHANOL, 4-(2-METHOXYPHENYL)-.ALPHA.-((1-NAPHTHALENYLOXY)METHYL)-, (.ALPHA.R)-;1-PIPERAZINEETHANOL, 4-(2-METHOXYPHENYL)-.ALPHA.-((1-NAPHTHALENYLOXY)METHYL)-, (R)-

Suppliers and Price of Naftopidil, (R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Naftopidil, (R)-

Chemical Property:

PSA：45.17000
LogP:3.41320
XLogP3:4.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:392.20999276
Heavy Atom Count:29
Complexity:483

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=CC=C1N2CCN(CC2)CC(COC3=CC=CC4=CC=CC=C43)O
Isomeric SMILES:COC1=CC=CC=C1N2CCN(CC2)C[C@H](COC3=CC=CC4=CC=CC=C43)O

Technology Process of Naftopidil, (R)-

There total 9 articles about Naftopidil, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2461-42-9
3-(1-naphthyloxy)-1,2-epoxypropane

: 127931-15-1
(R)-(+)-1-<4-(2-Methoxyphenyl)-1-piperazinyl>-3-(1-naphthyloxy)-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: 43 percent / water / (R,R)-salen-Co(III)OAc complex / 24 h / 20 °C

2: 85 percent / DIAD; triphenylphosphine / benzene / Heating

3: propan-2-ol / 30 h / Heating

With di-isopropyl azodicarboxylate; water; triphenylphosphine; (S,S)-(salen)cobalt(III)(OAc); In isopropyl alcohol; benzene; 2: Mitsunobu reaction;
DOI:10.1055/s-2005-870021

Reference yield:

: 90-04-0
2-methoxy-phenylamine

: 127931-15-1
(R)-(+)-1-<4-(2-Methoxyphenyl)-1-piperazinyl>-3-(1-naphthyloxy)-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / aq. Na₂CO₃; benzyltriethyl ammonium chloride / 24 h / 100 °C

2.1: K₂CO₃ / acetonitrile / Heating

2.2: zinc(II) perchlorate hexahydrate / 0.17 h / 80 °C

With N-benzyl-N,N,N-triethylammonium chloride; sodium carbonate; potassium carbonate; In acetonitrile;
DOI:10.1021/jo062674j

Reference yield:

: 90-15-3
α-naphthol

: 127931-15-1
(R)-(+)-1-<4-(2-Methoxyphenyl)-1-piperazinyl>-3-(1-naphthyloxy)-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / K₂CO₃ / butan-2-one / 12 h / Heating

2: 43 percent / water / (R,R)-salen-Co(III)OAc complex / 24 h / 20 °C

3: 85 percent / DIAD; triphenylphosphine / benzene / Heating

4: propan-2-ol / 30 h / Heating

With di-isopropyl azodicarboxylate; water; potassium carbonate; triphenylphosphine; (S,S)-(salen)cobalt(III)(OAc); In isopropyl alcohol; butanone; benzene; 3: Mitsunobu reaction;
DOI:10.1055/s-2005-870021