N-(2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-1-methyl-1H-imidazol-4-yl)-terephthalamic acid

Base Information

Chemical Name:N-(2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-1-methyl-1H-imidazol-4-yl)-terephthalamic acid
CAS No.:288623-94-9
Molecular Formula:C₂₈H₃₃N₁₁O₆
Molecular Weight:619.64
Hs Code.:

<i>N</i>-(2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1<i>H</i>-imidazol-4-ylcarbamoyl]-1-methyl-1<i>H</i>-imidazol-4-ylcarbamoyl}-1-methyl-1<i>H</i>-imidazol-4-yl)-terephthalamic acid

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Chemical Property of N-(2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-1-methyl-1H-imidazol-4-yl)-terephthalamic acid

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Technology Process of N-(2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-1-methyl-1H-imidazol-4-yl)-terephthalamic acid

There total 9 articles about N-(2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-1-methyl-1H-imidazol-4-yl)-terephthalamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 288623-86-9
N-(2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-1-methyl-1H-imidazol-4-yl)-terephthalamic acid methyl ester

: 288623-94-9
N-(2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-1-methyl-1H-imidazol-4-yl)-terephthalamic acid

Guidance literature:: With sodium hydroxide; water; for 18h; Heating;
DOI:10.1002/1099-0690(200006)2000:11<2095::AID-EJOC2095>3.0.CO;2-J

Reference yield:

: 128484-08-2
N-[3-(dimethylamino)propyl]-1-methyl-4-nitroimidazole-2-carboxamide

: 288623-94-9
N-(2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-1-methyl-1H-imidazol-4-yl)-terephthalamic acid

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / Pd/C / dimethylformamide; methanol

2: dimethylformamide / 18 h / 20 °C

3: H₂ / Pd/C / dimethylformamide; methanol

4: dimethylformamide; tetrahydrofuran / 20 °C

5: H₂ / Pd/C / dimethylformamide; methanol

6: 1-hydroxybenzotriazole; 1,3-dicyclohexylcarbodiimide / dimethylformamide / 18 h / 20 °C

7: 90 percent / sodium hydroxide; water / 18 h / Heating

With sodium hydroxide; water; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Hydrogenation / 2: Condensation / 3: Hydrogenation / 4: Condensation / 5: Hydrogenation / 6: Condensation / 7: Hydrolysis;
DOI:10.1002/1099-0690(200006)2000:11<2095::AID-EJOC2095>3.0.CO;2-J

Reference yield:

: 120095-64-9
2,2,2-trichloro-1-(1-methyl-4-nitro-1H-imidazol-2-yl)ethan-1-one

: 288623-94-9
N-(2-{2-[2-(3-dimethylamino-propylcarbamoyl)-1-methyl-1H-imidazol-4-ylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-1-methyl-1H-imidazol-4-yl)-terephthalamic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 98 percent / tetrahydrofuran / 2 h / 20 °C

2: H₂ / Pd/C / dimethylformamide; methanol

3: dimethylformamide / 18 h / 20 °C

4: H₂ / Pd/C / dimethylformamide; methanol

5: dimethylformamide; tetrahydrofuran / 20 °C

6: H₂ / Pd/C / dimethylformamide; methanol

7: 1-hydroxybenzotriazole; 1,3-dicyclohexylcarbodiimide / dimethylformamide / 18 h / 20 °C

8: 90 percent / sodium hydroxide; water / 18 h / Heating

With sodium hydroxide; water; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrogenation / 3: Condensation / 4: Hydrogenation / 5: Condensation / 6: Hydrogenation / 7: Condensation / 8: Hydrolysis;
DOI:10.1002/1099-0690(200006)2000:11<2095::AID-EJOC2095>3.0.CO;2-J