Thiourea

Base Information

• Chemical Name: Thiourea
• CAS No.: 62-56-6
• Deprecated CAS: 1032826-45-1,1429623-74-4,1803177-22-1
• Molecular Formula: CH4N2S
• Molecular Weight: 76.13
• Hs Code.: 29309070
• European Community (EC) Number: 200-543-5
• ICSC Number: 0680
• NSC Number: 5033
• UN Number: 2811,2877
• UNII: GYV9AM2QAG
• DSSTox Substance ID: DTXSID9021348
• Nikkaji Number: J2.351E
• Wikipedia: Thiourea
• Wikidata: Q528995
• NCI Thesaurus Code: C44455
• Metabolomics Workbench ID: 46387
• ChEMBL ID: CHEMBL260876
• Mol file: 62-56-6.mol

Synonyms:Thiourea

Chemical Property of Thiourea

Chemical Property:

• Appearance/Colour: white crystals or powder
• Melting Point: 171 °C
• Refractive Index: 1.582
• Boiling Point: 186.836 °C at 760 mmHg
• PKA: -1.0(at 25℃)
• Flash Point: 66.796 °C
• PSA: 84.13000
• Density: 1.326 g/cm³
• LogP: 0.58930
• Storage Temp.: Store at RT.
• Solubility.: water: soluble137g/L at 20°C
• Water Solubility.: 13.6 g/100 mL (20 ºC)
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 76.00951931
• Heavy Atom Count: 4
• Complexity: 29
• Transport DOT Label: Poison

Purity/Quality:

99% ^*data from raw suppliers

Thiourea ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, N
• Hazard Codes: Xn,N,Xi
• Statements: 22-40-51/53-63-43-38
• Safety Statements: 36/37-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Thiourea Compounds
• Canonical SMILES: C(=S)(N)N
• Inhalation Risk: Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly.
• Effects of Short Term Exposure: The substance is irritating to the eyes.
• Effects of Long Term Exposure: Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the thyroid. This substance is possibly carcinogenic to humans.
• Description: Thiourea appears as white crystal/powder, is combustible, and on contact with fire, gives off irritating or toxic fumes/gases. Thiourea is a reducing agent used primarily in the production of bleached recycled pulp. In addition, it is also effective in the bleaching of stone groundwood, pressurised groundwood. Thiourea undergoes decomposition on heating and produces toxic fumes of nitrogen oxides and sulphur oxides. It reacts violently with acrolein, strong acids, and strong oxidants. The main application of thiourea is in textile processing and also is commonly employed as a source of sulphide. Thiourea is a precursor to sulphide to produce metal sulphides, for example, mercury sulphide, upon reaction with the metal salt in aqueous solution. The industrial uses of thiourea include production of flame-retardant resins and vulcanisation accelerators. Thiourea is used as an auxiliary agent in diazo paper, light-sensitive photocopy paper, and almost all other types of copy paper. Thiourea is used in many industrial applications, including as a chemical intermediate or catalyst, in metal processing and plating, and in photoprocessing.
• Uses: The product is wildly used in pharmaceutical industry, agricultural, chemicals, metallurgical industry, petroleum and so on. It is also main material for producing thiourea dioxide(CH1N2O2S). Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins Used in determination of bismuth. In animal glue liquifiers and silver tarnish removers. Photographic fixing agent and to remove stains from negatives; manufacture of resins; vulcanization accelerator; a reagent for bismuth, selenite ions. Thiourea is used in the manufacture of resins,as a vulcanization accelerator, and as aphotographic fixing agent and to removestains from negatives. The most common uses for thiourea have been for the production of thiourea dioxide (30%), in leaching of gold and silver ores (25%), in diazo papers (15%), and as a catalyst in the synthesis of fumaric acid (10%) (IARC 2001). It has also been used in the production and modification of synthetic resins. Other uses of thiourea are as a photographic toning agent, in hair preparations, as a drycleaning agent, in the synthesis of pharmaceuticals and pesticides, in boiler-water treatment, and as a reagent for bismuth and selenite ions. It has also been used in textile and dyeing auxiliaries, in the production of industrial cleaning agents (e.g., for photographic tanks and metal surfaces in general), for engraving metal surfaces, as an isomerization catalyst in the conversion of maleic to fumaric acid, in copper-refining electrolysis, in electroplating, and as an antioxidant. Other uses have included as a vulcanization accelerator, an additive for slurry explosives,as a viscosity stabilizer for polymer solutions, and as a mobility buffer in petroleum extraction. It is also used as an ingredient of consumer silver polishes (HPD 2009), and has been used in the removal of mercury from wastewater by chlorine-alkali electrolysis (IARC 1974, 2001, WHO 2003).

Technology Process of Thiourea

There total 7 articles about Thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

isothiocyanic acid (3129-90-6) → thiourea (62-56-6)

Guidance literature:

With ammonia;

DOI:10.1080/00397911.2013.804933

Reference yield:

→ thiourea (62-56-6)

Guidance literature:

entspr. Diamin + CS2;

Reference yield:

→ (+)-pinanediol 4-(formamidino)thio-1(R)-(4-phenylbenzoyl) aminobutane-1-boronate + thiourea (62-56-6)

Guidance literature:

upstream raw materials:

isothiocyanic acid

Downstream raw materials:

4-(2-aminothiazol-4-yl)phenyl acetate

2-Amino-4-phenylthiazole

5-(phenylmethyl)-1,3-thiazol-2-amine

carbamimidothioic acid methyl ester

Refernces

• 1、 -. "Bicyclic compounds". . . Retrieved 2008/06/13.
• 2、 -. "[3H,7H]thiazolo[3,4-a]pyridines with antiasthmatic and antiinflammatory actions on the respiratory tract". . . Retrieved 2008/06/13.