6-BroMo-3-Methoxy-2-nitrobenzoic acid

Base Information

• Chemical Name: 6-BroMo-3-Methoxy-2-nitrobenzoic acid
• CAS No.: 127971-97-5
• Molecular Formula: C8H6BrNO5
• Molecular Weight: 276.043
• Hs Code.: 2918990090
• Mol file: 127971-97-5.mol

Synonyms:Pyridine,6-bromo-3-methoxy-2-methyl;

Chemical Property of 6-BroMo-3-Methoxy-2-nitrobenzoic acid

Chemical Property:

• PSA: 92.35000
• LogP: 2.58730
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-Bromo-3-methoxy-2-nitrobenzoicacid >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BroMo-3-Methoxy-2-nitrobenzoic acid

There total 3 articles about 6-BroMo-3-Methoxy-2-nitrobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methoxy-2-nitrobenzoic acid (4920-80-3) → 6-bromo-3-methoxy-2-nitrobenzoic acid (127971-97-5)

Guidance literature:

With sulfuric acid; bromine; silver sulfate; at 20 ℃; for 2h;

Reference yield: 99.0%

3-methoxy-2-nitrobenzoic acid (4920-80-3) → 4,6-dibromo-3-methoxy-2-nitrobenzoic acid + 6-bromo-3-methoxy-2-nitrobenzoic acid (127971-97-5)

Guidance literature:

3-methoxy-2-nitrobenzoic acid; With sulfuric acid; silver sulfate; at 10 - 20 ℃; for 0.0833333h; Inert atmosphere;

With bromine; at 20 ℃; for 4h; Inert atmosphere; Darkness;

DOI:10.1021/acs.orglett.8b02221

Reference yield:

1-methoxy-3-methyl-2-nitro-benzene (5345-42-6) → 4,6-dibromo-3-methoxy-2-nitrobenzoic acid + 6-bromo-3-methoxy-2-nitrobenzoic acid (127971-97-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium carbonate; potassium permanganate / water / 20 h / Inert atmosphere; Reflux

2.1: sulfuric acid; silver sulfate / 0.08 h / 10 - 20 °C / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere; Darkness

With potassium permanganate; sulfuric acid; sodium carbonate; silver sulfate; In water;

DOI:10.1021/acs.orglett.8b02221

upstream raw materials:

3-methoxy-2-nitrobenzoic acid

1-methoxy-3-methyl-2-nitro-benzene

Downstream raw materials:

methyl 6-bromo-3-methoxy-2-nitrobenzoate

Refernces

• 1、 -. "COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF PREPARING COMPOUNDS AND OF THEIR USE". Page/Page column 76; 139. . Retrieved 2021/10/11.
• 2、 -. "Benzoxazole carboxamides for treating CINV and IBS-D". Page/Page column 41-42. . Retrieved 2008/06/13.