N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-methyl-pyrrolidin-3-yl)-acetamide

Base Information

• Chemical Name: N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-methyl-pyrrolidin-3-yl)-acetamide
• CAS No.: 93592-70-2
• Molecular Formula: C₂₈H₂₃Cl₂N₃O₄
• Molecular Weight: 536.414
• Mol file: 93592-70-2.mol

Synonyms:

Chemical Property of N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-methyl-pyrrolidin-3-yl)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-methyl-pyrrolidin-3-yl)-acetamide

There total 1 articles about N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-methyl-pyrrolidin-3-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-phthaloylglycine chloride (6780-38-7) + [5-Chloro-2-(1-methyl-pyrrolidin-3-ylamino)-phenyl]-(2-chloro-phenyl)-methanone (93592-80-4) → N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-methyl-pyrrolidin-3-yl)-acetamide (93592-70-2)

Guidance literature:

In acetonitrile; Ambient temperature;

DOI:10.1021/jm00383a003

Reference yield:

N-[4-Chloro-2-(2-chloro-benzoyl)-phenyl]-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-N-(1-methyl-pyrrolidin-3-yl)-acetamide (93592-70-2) → 7-Chloro-5-(2-chloro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one (93592-49-5)

Guidance literature:

With hydrazine hydrate; In ethanol; for 2h; Yield given; Heating;

DOI:10.1021/jm00383a003

upstream raw materials:

N-phthaloylglycine chloride

[5-Chloro-2-(1-methyl-pyrrolidin-3-ylamino)-phenyl]-(2-chloro-phenyl)-methanone

Downstream raw materials:

7-Chloro-5-(2-chloro-phenyl)-1-(1-methyl-pyrrolidin-3-yl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one