(S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester
CAS No.:363189-67-7
Molecular Formula:C₃₉H₅₄FN₅O₅
Molecular Weight:691.887
Hs Code.:

(S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester

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Chemical Property of (S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester

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Technology Process of (S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester

There total 9 articles about (S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 167262-68-2
N-(t-butyloxycarbonyl)-4-phenylpiperidine-4-carboxylic acid

: 363189-67-7
(S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: H₂ / Rh/Al₂O₃ / methanol / 70 °C / 3620.04 Torr

2: (COCl)2; DMF / CH₂Cl₂

3: CH₂Cl₂

4: TFA / CH₂Cl₂

5: EDC; HOBt; DIEA / CH₂Cl₂

6: TFA / CH₂Cl₂

7: EDC; HOBt; DIEA / CH₂Cl₂

8: TFA / CH₂Cl₂

9: NaBH₃CN; NaOAc / methanol

With oxalyl dichloride; hydrogen; sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; Rh/Al₂O₃; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.10.020

Reference yield:

: 4-phenyl-4-piperidinecarboxylic acid 4-methylbenzenesulfonate

: 363189-67-7
(S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: NaOH / dioxane

2: H₂ / Rh/Al₂O₃ / methanol / 70 °C / 3620.04 Torr

3: (COCl)2; DMF / CH₂Cl₂

4: CH₂Cl₂

5: TFA / CH₂Cl₂

6: EDC; HOBt; DIEA / CH₂Cl₂

7: TFA / CH₂Cl₂

8: EDC; HOBt; DIEA / CH₂Cl₂

9: TFA / CH₂Cl₂

10: NaBH₃CN; NaOAc / methanol

With sodium hydroxide; oxalyl dichloride; hydrogen; sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; Rh/Al₂O₃; In 1,4-dioxane; methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.10.020

Reference yield:

: 363191-02-0
N-(tert-butyl)-4-cyclohexylpiperidine-4-carboxamide

: 363189-67-7
(S)-3-[(R)-2-(4-tert-Butylcarbamoyl-4-cyclohexyl-piperidin-1-yl)-1-(4-fluoro-benzyl)-2-oxo-ethylcarbamoyl]-4-methyl-piperazine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: EDC; HOBt; DIEA / CH₂Cl₂

2: TFA / CH₂Cl₂

3: EDC; HOBt; DIEA / CH₂Cl₂

4: TFA / CH₂Cl₂

5: NaBH₃CN; NaOAc / methanol

With sodium acetate; sodium cyanoborohydride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2004.10.020