(S)-4-{6-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one benzoate

Base Information

Chemical Name:(S)-4-{6-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one benzoate
CAS No.:1073631-79-4
Molecular Formula:C₇H₆O₂*C₂₆H₂₅N₅O₄
Molecular Weight:593.639
Hs Code.:

(S)-4-{6-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one benzoate

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Chemical Property of (S)-4-{6-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one benzoate

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Technology Process of (S)-4-{6-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one benzoate

There total 15 articles about (S)-4-{6-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073632-78-6
1,1-dimethylethyl (6-amino-1,2,3,4-tetrahydro-2-naphthalenyl)(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)carbamate

: 1073631-79-4
(S)-4-{6-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 2 h / 20 - 50 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 48 h / 20 °C

4.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

5.1: manganese(IV) oxide / dichloromethane / 1 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

6.2: MP-carbonate resin / pH 8

7.1: Resolution of racemate

With manganese(IV) oxide; potassium tert-butylate; hydrogen; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1073632-76-4
1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl){6-[(diphenylmethylidene)amino]-1,2,3,4-tetrahydro-2-naphthalenyl}carbamate

: 1073631-79-4
(S)-4-{6-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one benzoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 20 °C

1.2: pH 9

2.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 2 h / 20 - 50 °C

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 48 h / 20 °C

5.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

6.1: manganese(IV) oxide / dichloromethane / 1 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

7.2: MP-carbonate resin / pH 8

8.1: Resolution of racemate

With hydrogenchloride; manganese(IV) oxide; potassium tert-butylate; water; hydrogen; sodium hydrogencarbonate; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1073632-79-7
1,1-dimethylethyl (2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)(6-{[6-(methyloxy)-3-nitro-2-pyridinyl]amino}-1,2,3,4-tetrahydro-2-naphthalenyl)carbamate

: 1073631-79-4
(S)-4-{6-[(2,3-dihydro[1,4]dioxino[2,3-c]pyridin-7-ylmethyl)amino]-5,6,7,8-tetrahydro-2-naphthalenyl}-6-(methyloxy)pyrido[2,3-b]pyrazin-3(4H)-one benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide; acetonitrile / 48 h / 20 °C

3.1: potassium tert-butylate / tetrahydrofuran / 0 - 20 °C

4.1: manganese(IV) oxide / dichloromethane / 1 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C

5.2: MP-carbonate resin / pH 8

6.1: Resolution of racemate

With manganese(IV) oxide; potassium tert-butylate; hydrogen; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;