(E)-(2S,3R)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-phenyl-pent-4-enoic acid tert-butyl ester

Base Information

Chemical Name:(E)-(2S,3R)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-phenyl-pent-4-enoic acid tert-butyl ester
CAS No.:153498-41-0
Molecular Formula:C₃₈H₅₃NO₃Si
Molecular Weight:599.929
Hs Code.:

Synonyms:

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Chemical Property of (E)-(2S,3R)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-phenyl-pent-4-enoic acid tert-butyl ester

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Technology Process of (E)-(2S,3R)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-phenyl-pent-4-enoic acid tert-butyl ester

There total 1 articles about (E)-(2S,3R)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-phenyl-pent-4-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 153498-40-9
(E)-(2S,3R)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-2-((R)-1-hydroxy-ethyl)-5-phenyl-pent-4-enoic acid tert-butyl ester

: 153498-41-0
(E)-(2S,3R)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-phenyl-pent-4-enoic acid tert-butyl ester

Guidance literature:: With 1H-imidazole;
DOI:10.1039/c39930001660

Reference yield: 60.0%

: 153498-41-0
(E)-(2S,3R)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-phenyl-pent-4-enoic acid tert-butyl ester

: 153498-42-1
(2S,3R)-3-Amino-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-phenyl-pentanoic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium dihydroxide;
DOI:10.1039/c39930001660

Reference yield:

: 153498-41-0
(E)-(2S,3R)-3-[Benzyl-((R)-1-phenyl-ethyl)-amino]-2-[(R)-1-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-phenyl-pent-4-enoic acid tert-butyl ester

: (3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-phenethyl-azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / H₂ / Pd(OH)2/C

2: CF₃COOH / CH₂Cl₂

3: PPh₃, (2-pyridyl)disulfide / acetonitrile

With 2,2'-dipyridyldisulphide; hydrogen; triphenylphosphine; trifluoroacetic acid; palladium dihydroxide; In dichloromethane; acetonitrile;
DOI:10.1039/c39930001660