2-{3-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}propan-2-ol

Base Information

Chemical Name:2-{3-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}propan-2-ol
CAS No.:1034044-50-2
Molecular Formula:C₂₅H₁₉F₆N₅O₅S
Molecular Weight:615.513
Hs Code.:

2-{3-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}propan-2-ol

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Chemical Property of 2-{3-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}propan-2-ol

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Technology Process of 2-{3-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}propan-2-ol

There total 11 articles about 2-{3-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₂₁F₆N₅O₆S

: 1034044-50-2,1034152-93-6,1034152-95-8
2-{3-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}propan-2-ol

Guidance literature:: With potassium carbonate; In methanol; at 50 ℃; for 4h;
DOI:10.1021/ml200304j

Reference yield:

: 1034046-86-0
7-cyano-6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepine

: 1034044-50-2,1034152-93-6,1034152-95-8
2-{3-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine; potassium carbonate / ethanol; water / 0.33 h / 120 °C / Microwave irradiation

2: pyridine / 3 h / 80 °C

3: potassium carbonate / methanol / 4 h / 50 °C

With pyridine; hydroxylamine; potassium carbonate; In methanol; ethanol; water;
DOI:10.1021/ml200304j

Reference yield:

: 1034046-87-1
C₂₁H₁₅F₆N₅O₄S

: 1034044-50-2,1034152-93-6,1034152-95-8
2-{3-[6-{[4-(trifluoromethoxy)phenyl]sulfonyl}-2-(trifluoromethyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl}propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 3 h / 80 °C

2: potassium carbonate / methanol / 4 h / 50 °C

With pyridine; potassium carbonate; In methanol;
DOI:10.1021/ml200304j