Technology Process of 8,12-Dides(2-carboxyethyl)-8,12-bis[2-(methoxycarbonyl)ethyl]-31,32,181,182-tetrahydrobiliverdin
There total 19 articles about 8,12-Dides(2-carboxyethyl)-8,12-bis[2-(methoxycarbonyl)ethyl]-31,32,181,182-tetrahydrobiliverdin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen; methacrylic acid methyl ester;
palladium on activated charcoal;
In
formic acid;
at 50 ℃;
for 0.833333h;
DOI:10.1246/bcsj.61.3539
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 54 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 18 h / 20 °C
2: 50 percent / p-toluensulfonic acid / CH2Cl2 / 4 h / 40 °C
3: 76 percent / H2, triethylamine / 10percent Pd on charcoal / tetrahydrofuran / 3 h / 2585.7 Torr
4: p-toluensulfonic acid hydrate 48 percent hydrobromic acid / CH2Cl2; methanol / 14 h / 20 °C
5: Br2 / trifluoroacetic acid / 1 h / 0 - 2 °C
With
hydrogen bromide; hydrogen; bromine; toluene-4-sulfonic acid; triethylamine; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; trifluoroacetic acid;
DOI:10.1016/S0040-4020(01)87636-5
