7,7-dimethyl-4-(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one

Base Information

• Chemical Name: 7,7-dimethyl-4-(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one
• CAS No.: 1309783-34-3
• Molecular Formula: C₂₆H₂₅N₃O₂S
• Molecular Weight: 443.569
• Mol file: 1309783-34-3.mol

Synonyms:

Chemical Property of 7,7-dimethyl-4-(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7,7-dimethyl-4-(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one

There total 3 articles about 7,7-dimethyl-4-(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

6-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde (101382-53-0) + dimedone (126-81-8) + monophenylthiourea (103-85-5) → 7,7-dimethyl-4-(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one (1309783-34-3)

Guidance literature:

With zinc trifluoromethanesulfonate; In ethanol; Reflux;

DOI:10.1007/s00044-011-9628-y

Reference yield:

2-chloro-6-methylquinoline-3-carbaldehyde (73568-27-1) → 7,7-dimethyl-4-(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one (1309783-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / Reflux

2: zinc trifluoromethanesulfonate / ethanol / Reflux

With zinc trifluoromethanesulfonate; acetic acid; In ethanol;

DOI:10.1007/s00044-011-9628-y

Reference yield:

4-Methylacetanilide (103-89-9) → 7,7-dimethyl-4-(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydroquinazolin-5(6H)-one (1309783-34-3)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 6 h / 0 - 75 °C

2: acetic acid / Reflux

3: zinc trifluoromethanesulfonate / ethanol / Reflux

With zinc trifluoromethanesulfonate; acetic acid; trichlorophosphate; In ethanol;

DOI:10.1007/s00044-011-9628-y

upstream raw materials:

2-chloro-6-methylquinoline-3-carbaldehyde

6-methyl-2-oxo-1,2-dihydroquinoline-3-carbaldehyde

dimedone

monophenylthiourea