AS1940477 Hydrobromide

Base Information

• Chemical Name: AS1940477 Hydrobromide
• CAS No.: 1404189-10-1
• Molecular Formula: BrH*C₂₄H₂₂FN₅O₂
• Molecular Weight: 512.381
• Mol file: 1404189-10-1.mol

Synonyms:

Chemical Property of AS1940477 Hydrobromide

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

AS1940477Hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: AS1940477 Hydrobromide is a novel and potent p38 mitogen-activated protein kinase (MAPK) inhibitor.

Technology Process of AS1940477 Hydrobromide

There total 12 articles about AS1940477 Hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

A(404)S1977 (928344-12-1) → (R)-6-[2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one monohydrobromide (1404189-10-1)

Guidance literature:

With hydrogen bromide; In propan-1-ol; water; at 25 - 65 ℃; for 25h; Large scale;

DOI:10.1021/op300237b

Reference yield:

6-[2-(4-fluorophenyl)-2-oxoethyl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one (882974-67-6) → (R)-6-[2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one monohydrobromide (1404189-10-1)

Guidance literature:

Multi-step reaction with 5 steps

1: bromine; acetic acid / 4 h / 25 °C / Large scale

2: hydrogen bromide / water; ethanol / 8 h / 40 °C

3: acetonitrile / 60 °C

4: hydrogenchloride; water / ethanol / 24 h / 45 - 60 °C / Large scale

5: hydrogen bromide / water; propan-1-ol / 25 h / 25 - 65 °C / Large scale

With hydrogenchloride; water; hydrogen bromide; bromine; acetic acid; In propan-1-ol; ethanol; water; acetonitrile;

DOI:10.1021/op300237b

Reference yield:

2-(6-chloropyridazin-3-yl)-1-(4-fluorophenyl)ethan-1-one (882974-10-9) → (R)-6-[2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one monohydrobromide (1404189-10-1)

Guidance literature:

Multi-step reaction with 9 steps

1: acetic acid; sodium acetate / water / 5 h / 100 - 108 °C / Large scale

2: toluene-4-sulfonic acid / toluene / 12 h / 105 - 111 °C / Large scale

3: pyridine; copper diacetate / N,N-dimethyl-formamide / 37 h / 25 °C / Large scale

4: hydrogenchloride; water / methanol / 8 h / 25 °C / Large scale

5: bromine; acetic acid / 4 h / 25 °C / Large scale

6: acetic acid / ethanol / 72 h / 60 °C

7: acetonitrile / 60 °C

8: hydrogenchloride; water / ethanol / 24 h / 45 - 60 °C / Large scale

9: hydrogen bromide / water; propan-1-ol / 25 h / 25 - 65 °C / Large scale

With pyridine; hydrogenchloride; water; hydrogen bromide; bromine; copper diacetate; sodium acetate; toluene-4-sulfonic acid; acetic acid; In methanol; propan-1-ol; ethanol; water; N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1021/op300237b

upstream raw materials:

6-{[2-(4-fluorophenyl)-1,3-dioxolan-2-yl]methyl}-2-(2-tolyl)-2,3-dihydropyridazin-3-one

6-[2-(4-fluorophenyl)-2-oxoethyl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one

(RS)-6-[1-bromo-2-(4-fluorophenyl)-2-oxoethyl]-2-(2-tolyl)-2,3-dihydropyridazin-3-one

3-chloro-6-methylpyridazine