2-fluorophenyl phosphorochloridate

Base Information

• Chemical Name: 2-fluorophenyl phosphorochloridate
• CAS No.: 53676-17-8
• Molecular Formula: C₆H₄Cl₂FO₂P
• Molecular Weight: 228.975
• Mol file: 53676-17-8.mol

Synonyms:

Chemical Property of 2-fluorophenyl phosphorochloridate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-fluorophenyl phosphorochloridate

There total 1 articles about 2-fluorophenyl phosphorochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-fluorophenol (367-12-4) → 2-fluorophenyl phosphorochloridate (53676-17-8)

Guidance literature:

With lithium chloride; trichlorophosphate; for 48h; Reflux;

DOI:10.1016/j.poly.2010.04.002

Reference yield: 61.0%

2,3-O-isopropylidene-D-ribofuranose (67814-68-0,70266-87-4,76249-50-8,76249-51-9,93451-15-1,4099-88-1) + 2-fluorophenyl phosphorochloridate (53676-17-8) → 2,3-O-isopropylidene-β-D-ribofuranose cyclic 1,5-(2-fluorophenyl)phosphate (101155-32-2)

Guidance literature:

With pyridine; In dichloromethane; 0 deg C, 12 h, RT, 12 h;

DOI:10.1246/cl.1985.1087

Reference yield: 53.0%

2-fluorophenyl phosphorochloridate (53676-17-8) + benzylamine (100-46-9) → 2-FC6H4OP(O)(NHBn)2 (1240379-68-3)

Guidance literature:

In toluene; at 20 ℃; for 12h; Ambient conditions;

DOI:10.1016/j.poly.2010.04.002

upstream raw materials:

2-fluorophenol

Downstream raw materials:

Phosphorsaeure-mono-<2-fluor-phenylester>

2,3-O-isopropylidene-β-D-ribofuranose cyclic 1,5-(2-fluorophenyl)phosphate

Phosphoric acid (3aR,4R,6S,6aR)-6-(3,5-dimethyl-pyrazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester 2-fluoro-phenyl ester; compound with triethyl-amine

triethylammonium salt of 1-<5-O-(2-fluorophenyl)phosphono-2,3-O-isopropylidene-α-D-ribofuranosyl>-5,6-dimethylbenzimidazole