3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxopropyl)-1-piperazinyl]-, ethyl ester

Base Information

Chemical Name:3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxopropyl)-1-piperazinyl]-, ethyl ester
CAS No.:1089336-34-4
Molecular Formula:C₂₂H₂₆FN₃O₄
Molecular Weight:415.465
Hs Code.:
Mol file:1089336-34-4.mol

Synonyms:

Suppliers and Price of 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxopropyl)-1-piperazinyl]-, ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxopropyl)-1-piperazinyl]-, ethyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxopropyl)-1-piperazinyl]-, ethyl ester

There total 2 articles about 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxopropyl)-1-piperazinyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1‐cyclopropyl‐6‐fluoro‐4‐oxo‐7‐(4‐propionylpiperazin‐1‐yl)‐1,4‐dihydroquinoline‐3‐carboxylic acid

: 64-17-5
ethanol

: 1089336-34-4
ethyl 1‐cyclopropyl‐6‐fluoro‐4‐oxo‐7‐(4‐propionylpiperazin‐1‐yl)‐1,4‐dihydroquinoline‐3‐carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1111/cbdd.13534

Reference yield:

: 85721-33-1,178489-05-9,189257-90-7
ciprofloxacin

: 1089336-34-4
ethyl 1‐cyclopropyl‐6‐fluoro‐4‐oxo‐7‐(4‐propionylpiperazin‐1‐yl)‐1,4‐dihydroquinoline‐3‐carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: TEA / tetrahydrofuran / 20 °C

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C / Inert atmosphere

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1111/cbdd.13534