Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine

Base Information

Chemical Name:Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine
CAS No.:78481-24-0
Molecular Formula:C₅H₅N*C₅₂H₄₈ClN₆O₁₂P
Molecular Weight:1094.51
Hs Code.:

Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine

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Chemical Property of Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine

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Technology Process of Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine

There total 3 articles about Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75933-82-3
5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N⁴-benzoylguanosine-3'-(4-chlorophenyl 5-chloro-8-quinolyl-phosphate)

: 78481-24-0
Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine

Guidance literature:: With N₁,N₁,N₃,N₃-tetrametylquanidium salt of 2-pyridinecarboxaldehyde oxim; In 1,4-dioxane; methanol; at 20 ℃; for 16h; Yield given;
DOI:10.1246/cl.1981.543

Reference yield:

: 71933-62-5
5'-O-(dimethoxytrityl)-2'-O-(tetrahydropyranyl)-N²-benzoylguanosine

: 78481-24-0
Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triethylamine, 2.) tetrazole, triethylamine / 1.) THF, -10 deg C, 15 min; room temperature 45 min, 2.) THF, 10 min, 3.) THF, room temperature, 30 min

2: 1 M N¹,N¹,N³,N³-tetramethylguanidium salt of 2-pyridinaldoxime (PAO) / dioxane; methanol / 16 h / 20 °C

With 1H-tetrazole; N₁,N₁,N₃,N₃-tetrametylquanidium salt of 2-pyridinecarboxaldehyde oxim; triethylamine; In 1,4-dioxane; methanol;
DOI:10.1246/cl.1981.543

Reference yield:

: 130-16-5
5-Chloro-8-hydroxyquinoline

: 78481-24-0
Phosphoric acid (2R,3R,4R,5R)-5-(2-benzoylamino-6-oxo-1,6-dihydro-purin-9-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl ester 5-chloro-quinolin-8-yl ester; compound with pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) triethylamine, 2.) tetrazole, triethylamine / 1.) THF, -10 deg C, 15 min; room temperature 45 min, 2.) THF, 10 min, 3.) THF, room temperature, 30 min

2: 1 M N¹,N¹,N³,N³-tetramethylguanidium salt of 2-pyridinaldoxime (PAO) / dioxane; methanol / 16 h / 20 °C

With 1H-tetrazole; N₁,N₁,N₃,N₃-tetrametylquanidium salt of 2-pyridinecarboxaldehyde oxim; triethylamine; In 1,4-dioxane; methanol;
DOI:10.1246/cl.1981.543