1H-Indol-5-yl methanesulfonate

Base Information

• Chemical Name: 1H-Indol-5-yl methanesulfonate
• CAS No.: 128810-31-1
• Molecular Formula: C9H9NO3S
• Molecular Weight: 211.241
• Hs Code.: 2933990090
• Mol file: 128810-31-1.mol

Synonyms:1H-indol-5-ol, methanesulfonate (ester); 1H-Indol-5-yl methanesulfonate

Chemical Property of 1H-Indol-5-yl methanesulfonate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.648
• Boiling Point: 433.797°C at 760 mmHg
• Flash Point: 216.153°C
• PSA: 67.54000
• Density: 1.438g/cm³
• LogP: 2.58710
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

1H-Indol-5-ylmethanesulfonate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Indol-5-yl methanesulfonate

There total 1 articles about 1H-Indol-5-yl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

indol-5-ol (1953-54-4) + methanesulfonyl chloride (124-63-0) → 1H-indol-5-yl methanesulfonate (128810-31-1)

Guidance literature:

In dichloromethane;

DOI:10.1016/0040-4039(90)80006-8

Reference yield: 93.0%

potassiumhexacyanoferrate(II) trihydrate + 1H-indol-5-yl methanesulfonate (128810-31-1) → 1H-indole-5-carbonitrile (15861-24-2,142396-06-3)

Guidance literature:

With 2-[2-(dicyclohexylphosphino)-phenyl]-1-methyl-1H-indole; palladium diacetate; potassium carbonate; In water; tert-butyl alcohol; at 80 ℃; for 18h; Inert atmosphere;

DOI:10.1002/anie.201005121

Reference yield: 88.0%

(+) methyl(R)-2-methyl-2-[4-(3-methanesulfonyloxypropyl)phenoxy]butanoate + 1H-indol-5-yl methanesulfonate (128810-31-1) → (+) methyl-(R)-2-methyl-2-[4-{3-(5-methanesulfonyloxyindol-1-yl)propyl}phenoxy]butanoate

Guidance literature:

1H-indol-5-yl methanesulfonate; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

(+) methyl(R)-2-methyl-2-[4-(3-methanesulfonyloxypropyl)phenoxy]butanoate; In dimethyl sulfoxide; at 20 ℃; for 2h;

upstream raw materials:

indol-5-ol

methanesulfonyl chloride

Downstream raw materials:

5-(furan-3-yl)-1H-indole

1H-indole-5-carbonitrile

tert-butyl ((1H-indol-5-yl)methyl)carbamate

Refernces

• 1、 Molander, Gary A.,Beaumard, Floriane. "Nickel-catalyzed C-O activation of phenol derivatives with potassium heteroaryltrifluoroborates". supporting information; experimental part. p. 4022 - 4025. Retrieved 2010/11/05.
• 2、 -. "NOVEL COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM". Page/Page column 50-51. . Retrieved 2010/02/11.