Technology Process of rac-(2S)-(8β,8'α)-4-benzoyloxy-3,5-dimethoxy-4',5'-methylenedioxy-2,2'-cyclolignan-9,9'-olide
There total 7 articles about rac-(2S)-(8β,8'α)-4-benzoyloxy-3,5-dimethoxy-4',5'-methylenedioxy-2,2'-cyclolignan-9,9'-olide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
boron trifluoride diethyl etherate; thallium(III) trifluoroacetate;
In
dichloromethane;
1.) -40 deg C, 1 h, 2.) 3 h, room temp.;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) litium diisopropylamide, 2.) hexamethylphosphoric triamide / 1.) THF, -78 deg C, 1.5 h, 2.) 1 h, 2.) -26 deg C, 2 h
2: 9 percent / boron trifluoride etherate, thallium tristrifluoroacetate / CH2Cl2 / 1.) -40 deg C, 1 h, 2.) 3 h, room temp.
With
N,N,N,N,N,N-hexamethylphosphoric triamide; boron trifluoride diethyl etherate; lithium diisopropyl amide; thallium(III) trifluoroacetate;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1.) litium diisopropylamide, 2.) hexamethylphosphoric triamide / 1.) THF, -78 deg C, 1.5 h, 2.) 1 h, 2.) -26 deg C, 2 h
2: 9 percent / boron trifluoride etherate, thallium tristrifluoroacetate / CH2Cl2 / 1.) -40 deg C, 1 h, 2.) 3 h, room temp.
With
N,N,N,N,N,N-hexamethylphosphoric triamide; boron trifluoride diethyl etherate; lithium diisopropyl amide; thallium(III) trifluoroacetate;
In
dichloromethane;
