80483-34-7

Basic information

• Product Name: 4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)DIHYDROFURAN-2(3H)-ONE
• Synonyms: 4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)DIHYDROFURAN-2(3H)-ONE
• CAS NO: 80483-34-7
• Molecular Formula: C₁₂H₁₂O₄
• Molecular Weight: 220.22128
• Mol File: 80483-34-7.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)DIHYDROFURAN-2(3H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)DIHYDROFURAN-2(3H)-ONE(80483-34-7)
• EPA Substance Registry System: 4-(BENZO[D][1,3]DIOXOL-5-YLMETHYL)DIHYDROFURAN-2(3H)-ONE(80483-34-7)

Safety Data

• Hazardous Substances Data: 80483-34-7(Hazardous Substances Data)

Upstream product

• 120-57-0 piperonal 
• 123-25-1 succinic acid diethyl ester 
• 70148-36-6 4-(benzo[d][1,3]dioxol-5-ylmethyl)-tetrahydrofuran-2-ol 
• 2606-51-1 3,4-Methylenedioxybenzyl bromide 
• 1357013-37-6 3,4-methylenedioxyphenylzinc iodide 
• 166884-72-6 1-(1-(allyloxy)-2-iodoethoxy)butane 
• 94-59-7 1-allyl-3,4-methylenedioxybenzene 
• 157020-87-6 2,2-dichloro-3-(3,4-methylenedioxybenzyl)cyclobutanone 
• 100257-69-0 2-piperonyl-butane-1,4-diol 
• 84736-28-7 (methylenedioxy-3,4 benzylidene) α-hemisuccinate de methyle 
• 15930-53-7 6-bromo-3,4-methylenedioxybenzaldehyde 
• 61038-91-3 piperonal dimethyldithioacetal 
• 70381-89-4 methyl hydrogen (E)-2-<3,4-(methylenedioxy)benzylidene>succinate 
• 365423-58-1 5-[(E)-3-(2-Bromo-1-ethoxy-ethoxy)-propenyl]-benzo[1,3]dioxole 

Downstream Products

• 72011-45-1 <(benzyloxy-4 phenyl) hydroxymethyl>-3 (methylenedioxy-3,4 benzyl)-4 dihydro-3H-furannone-2 
• 131523-35-8 (+/-)-trans-2-(4-benzyloxy-3,5-dimethoxybenzyl)-3-piperonyl-4-butanolide 
• 144539-72-0 4-Benzo[1,3]dioxol-5-ylmethyl-3-[hydroxy-(3,4,5-trimethoxy-phenyl)-methyl]-dihydro-furan-2-one 
• 580-73-4 hinokinin 
• 26543-89-5 (-)-hinokinin 
• 477-51-0 rac-(7'β,8α,8'percentb)-3',4',5'-trimethoxy-4,5-methylenedioxy-2,7'-cyclolignan-9',9-olide 
• 17301-91-6 (3R*,4R*)-3-(3,4,5-trimethoxybenzyl)-4-(3,4-methylenedioxybenzyl)-4,5-dihydro-2(3H)-furanone 
• 119030-81-8 rac-(2S)-(8β,8'α)-4-benzoyloxy-3,5-dimethoxy-4',5'-methylenedioxy-2,2'-cyclolignan-9,9'-olide 
• 6512-69-2 di-O-methylthujaplicantin methyl ether 
• 16108-39-7 3-(3,4-methylenedioxybenzoyl)-4-butanolide 
• 40456-51-7 (3S,4S)-4-(benzo[d][1,3]dioxol-5-ylmethyl)-3-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one 

Relevant articles and documents

Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation

A complementary study including design of mechanistic probes, biochemical assays, model analysis, and liquid chromatography coupled mass spectrometry was conducted to establish the reaction mechanism for a nonheme iron enzyme catalyzed (?)-podophyllotoxin

Affinity-Driven Covalent Modulator of the Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Cascade

Traditional medicines provide a fertile ground to explore potent lead compounds, yet their transformation into modern drugs is fraught with challenges in deciphering the target that is mechanistically valid for its biological activity. Herein we reveal that (Z)-(+)-isochaihulactone (1) exhibited significant inhibition against multiple-drug-resistant (MDR) cancer cell lines and mice xenografts. NMR spectroscopy showed that 1 resisted an off-target thiolate, thus indicating that 1 was a target covalent inhibitor (TCI). By identifying the pharmacophore of 1 (α,β-unsaturated moiety), a probe derived from 1 was designed and synthesized for TCI-oriented activity-based proteome profiling. By MS/MS and computer-guided molecular biology approaches, an affinity-driven Michael addition of the noncatalytic C247 residue of GAPDH was found to control the “ON/OFF” switch of apoptosis through non-canonically nuclear GAPDH translocation, which bypasses the common apoptosis-resistant route of MDR cancers.

Enantioselective baeyer-villiger oxidation: Desymmetrization of meso cyclic ketones and kinetic resolution of racemic 2-arylcyclohexanones

Catalytic enantioselective Baeyer-Villiger (BV) oxidations of racemic and meso cyclic ketones were achieved in the presence of chiral N,N'-dioxide-Sc III complex catalysts. The BV oxidations of prochiral cyclohexanones and cyclobutanones afforded series of optically active μ- and γ-lactones, respectively, in up to 99% yield and 95% ee. Meanwhile, the kinetic resolution of racemic 2-arylcyclohexanones was also realized via an abnormal BV oxidation. Enantioenriched 3-aryloxepan-2-ones, whose formation is counter to the migratory aptitude, were obtained preferentially. Both the lactones and the unreacted ketones were obtained with high ee values.