3-(4-carboxymethyl-3,5-dimethylphenyl)propionic acid

Base Information

• Chemical Name: 3-(4-carboxymethyl-3,5-dimethylphenyl)propionic acid
• CAS No.: 100217-86-5
• Molecular Formula: C₁₃H₁₆O₄
• Molecular Weight: 236.268
• Mol file: 100217-86-5.mol

Synonyms:

Chemical Property of 3-(4-carboxymethyl-3,5-dimethylphenyl)propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-carboxymethyl-3,5-dimethylphenyl)propionic acid

There total 4 articles about 3-(4-carboxymethyl-3,5-dimethylphenyl)propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethyl (4-cyanomethyl-3,5-dimethylphenylmethyl)malonate (100217-85-4) → 3-(4-carboxymethyl-3,5-dimethylphenyl)propionic acid (100217-86-5)

Guidance literature:

With hydrogenchloride; In acetic acid; for 36h; Heating;

Reference yield:

1-bromomethyl-3,5-dimethylbenzene (27129-86-8) → 3-(4-carboxymethyl-3,5-dimethylphenyl)propionic acid (100217-86-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 15.8 g / potassium carbonate / dimethylformamide / 9 h / 150 °C

2: 1.) hydrogen chloride gas, anhydrous zinc chloride / 1.) tetrachloroethane, 80 deg C, 4.5 h; 2.) dimethylsulfoxide, 20 deg C, 20 min, 37 deg C, 3 h

3: 500 mg / cc. hydrochloric acid / acetic acid / 36 h / Heating

With hydrogenchloride; potassium carbonate; zinc(II) chloride; In acetic acid; N,N-dimethyl-formamide;

Reference yield:

diethyl (3,5-dimethylphenylmethyl)malonate (100217-83-2) → 3-(4-carboxymethyl-3,5-dimethylphenyl)propionic acid (100217-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) hydrogen chloride gas, anhydrous zinc chloride / 1.) tetrachloroethane, 80 deg C, 4.5 h; 2.) dimethylsulfoxide, 20 deg C, 20 min, 37 deg C, 3 h

2: 500 mg / cc. hydrochloric acid / acetic acid / 36 h / Heating

With hydrogenchloride; zinc(II) chloride; In acetic acid;

upstream raw materials:

diethyl (4-cyanomethyl-3,5-dimethylphenylmethyl)malonate

1-bromomethyl-3,5-dimethylbenzene

diethyl (3,5-dimethylphenylmethyl)malonate

1,3,5-trimethyl-benzene

Downstream raw materials:

2-benzylidene-6-methoxycarbonylmethyl-5,7-dimethylindan-1-one

Refernces