Technology Process of diethyl (4-cyanomethyl-3,5-dimethylphenylmethyl)malonate
There total 3 articles about diethyl (4-cyanomethyl-3,5-dimethylphenylmethyl)malonate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 15.8 g / potassium carbonate / dimethylformamide / 9 h / 150 °C
2: 1.) hydrogen chloride gas, anhydrous zinc chloride / 1.) tetrachloroethane, 80 deg C, 4.5 h; 2.) dimethylsulfoxide, 20 deg C, 20 min, 37 deg C, 3 h
With
hydrogenchloride; potassium carbonate; zinc(II) chloride;
In
N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 g / N-bromosuccinimide, benzoil peroxide / CCl4 / 1 h / Heating
2: 15.8 g / potassium carbonate / dimethylformamide / 9 h / 150 °C
3: 1.) hydrogen chloride gas, anhydrous zinc chloride / 1.) tetrachloroethane, 80 deg C, 4.5 h; 2.) dimethylsulfoxide, 20 deg C, 20 min, 37 deg C, 3 h
With
hydrogenchloride; N-Bromosuccinimide; potassium carbonate; zinc(II) chloride; dibenzoyl peroxide;
In
tetrachloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
With
hydrogenchloride; zinc(II) chloride;
Multistep reaction;
1.) tetrachloroethane, 80 deg C, 4.5 h; 2.) dimethylsulfoxide, 20 deg C, 20 min, 37 deg C, 3 h;