C₂₄H₂₄F₄N₄O₅S₂

Base Information

• Chemical Name: C₂₄H₂₄F₄N₄O₅S₂
• CAS No.: 935516-14-6
• Molecular Formula: C₂₄H₂₄F₄N₄O₅S₂
• Molecular Weight: 588.604
• Mol file: 935516-14-6.mol

Synonyms:

Chemical Property of C₂₄H₂₄F₄N₄O₅S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₄F₄N₄O₅S₂

There total 5 articles about C₂₄H₂₄F₄N₄O₅S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C17H16ClF4N3O3S (935513-62-5) + 3-(methylsulfonamido)phenylboronic acid (148355-75-3) → C24H24F4N4O5S2 (935516-14-6)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; at 100 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.bmcl.2014.05.072

Reference yield:

3-(methylsulfonamido)phenylboronic acid (148355-75-3) → C24H24F4N4O5S2 (935516-14-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; 1,4-dioxane / Reflux

2: dimethylsulfide borane complex / tetrahydrofuran / Reflux

3: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2014.05.072

Reference yield:

(2-chloro-6-(trifluoromethyl)pyridin-3-yl)methanamine (771572-85-1) → C24H24F4N4O5S2 (935516-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; N,N-dimethyl-formamide

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / toluene; ethanol / 1 h / 100 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2014.05.072

upstream raw materials:

3-(methylsulfonamido)phenylboronic acid

C₁₇H₁₆ClF₄N₃O₃S

(2-chloro-6-(trifluoromethyl)pyridin-3-yl)methanamine

2-[3-fluoro-4-(methylsulfonylamino)phenyl]propionic acid