[(4aR,10R,10aR)-10-(3,4-Dimethoxy-phenyl)-7,8-dimethoxy-2,2-dimethyl-4,4a,5,10-tetrahydro-naphtho[2,3-d][1,3]dioxin-10a-yl]-methanol

Base Information

• Chemical Name: [(4aR,10R,10aR)-10-(3,4-Dimethoxy-phenyl)-7,8-dimethoxy-2,2-dimethyl-4,4a,5,10-tetrahydro-naphtho[2,3-d][1,3]dioxin-10a-yl]-methanol
• CAS No.: 124281-61-4
• Molecular Formula: C₂₅H₃₂O₇
• Molecular Weight: 444.525
• Mol file: 124281-61-4.mol

Synonyms:

Chemical Property of [(4aR,10R,10aR)-10-(3,4-Dimethoxy-phenyl)-7,8-dimethoxy-2,2-dimethyl-4,4a,5,10-tetrahydro-naphtho[2,3-d][1,3]dioxin-10a-yl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(4aR,10R,10aR)-10-(3,4-Dimethoxy-phenyl)-7,8-dimethoxy-2,2-dimethyl-4,4a,5,10-tetrahydro-naphtho[2,3-d][1,3]dioxin-10a-yl]-methanol

There total 2 articles about [(4aR,10R,10aR)-10-(3,4-Dimethoxy-phenyl)-7,8-dimethoxy-2,2-dimethyl-4,4a,5,10-tetrahydro-naphtho[2,3-d][1,3]dioxin-10a-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

gmelinol (469-28-3,597-01-3,17669-45-3,24192-66-3,81495-56-9,96894-16-5,144940-45-4) → [(4aR,10R,10aR)-10-(3,4-Dimethoxy-phenyl)-7,8-dimethoxy-2,2-dimethyl-4,4a,5,10-tetrahydro-naphtho[2,3-d][1,3]dioxin-10a-yl]-methanol (124281-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BF₃-etherate, 2.) triethylsilane / 1.) CH₂Cl₂, 0 deg C, 1 h, 2.) RT, 14 h

2: p-toluenesulfonic acid / 14 h / Ambient temperature

With triethylsilane; boron trifluoride diethyl etherate; toluene-4-sulfonic acid;

DOI:10.1016/S0040-4020(01)81024-3

Reference yield:

(1R,2R,3R)-1-(3,4-Dimethoxy-phenyl)-2,3-bis-hydroxymethyl-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol (124281-57-8) + acetone (67-64-1) → [(4aR,10R,10aR)-10-(3,4-Dimethoxy-phenyl)-7,8-dimethoxy-2,2-dimethyl-4,4a,5,10-tetrahydro-naphtho[2,3-d][1,3]dioxin-10a-yl]-methanol (124281-61-4) + C25H32O7 (124281-60-3)

Guidance literature:

toluene-4-sulfonic acid; for 14h; Ambient temperature;

DOI:10.1016/S0040-4020(01)81024-3

upstream raw materials:

(1R,2R,3R)-1-(3,4-Dimethoxy-phenyl)-2,3-bis-hydroxymethyl-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalen-2-ol

acetone

gmelinol