Technology Process of 7a-benzyl-2a-methoxy-2a,6,7,7b-tetrahydro-2H-cyclopentinden-2-one
There total 7 articles about 7a-benzyl-2a-methoxy-2a,6,7,7b-tetrahydro-2H-cyclopentinden-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol;
at 60 ℃;
for 1h;
Yield given;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 83 percent / potassium, t-butyl alcohol, lithium bromide / liquid ammonia; tetrahydrofuran; H2O / from -78 deg C to room temp.
2: lithium di-isopropylamide / tetrahydrofuran / 0.5 h / -90 - 0 °C
3: pyridine, 30percent H2O2 / tetrahydrofuran / 0 °C
4: t-butyl-lithium / tetrahydrofuran / 0.17 h / -78 °C
5: dimsyl sodium / dimethylsulfoxide / Ambient temperature
6: 2M HCl / tetrahydrofuran / 0.5 h / Ambient temperature
7: 5percent aq. methanolic potassium hydroxide / methanol / 1 h / 60 °C
With
pyridine; hydrogenchloride; potassium hydroxide; dihydrogen peroxide; tert.-butyl lithium; potassium; sodium methylsulfinylmethanide; lithium bromide; tert-butyl alcohol; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; ammonia; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: lithium di-isopropylamide / tetrahydrofuran / 0.5 h / -90 - 0 °C
2: pyridine, 30percent H2O2 / tetrahydrofuran / 0 °C
3: t-butyl-lithium / tetrahydrofuran / 0.17 h / -78 °C
4: dimsyl sodium / dimethylsulfoxide / Ambient temperature
5: 2M HCl / tetrahydrofuran / 0.5 h / Ambient temperature
6: 5percent aq. methanolic potassium hydroxide / methanol / 1 h / 60 °C
With
pyridine; hydrogenchloride; potassium hydroxide; dihydrogen peroxide; tert.-butyl lithium; sodium methylsulfinylmethanide; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; dimethyl sulfoxide;
