5-({9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-methyl)-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:5-({9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-methyl)-1H-pyrimidine-2,4-dione
CAS No.:233756-59-7
Molecular Formula:C₄₄H₄₂N₈O₁₀
Molecular Weight:842.865
Hs Code.:

5-({9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9<i>H</i>-purin-2-ylamino}-methyl)-1<i>H</i>-pyrimidine-2,4-dione

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Chemical Property of 5-({9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-methyl)-1H-pyrimidine-2,4-dione

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Technology Process of 5-({9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-methyl)-1H-pyrimidine-2,4-dione

There total 4 articles about 5-({9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-methyl)-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108310-92-5
2-amino-6-(2-(p-nitrophenyl)ethyloxy)-9-[2'-deoxy-β-D-erythropentofuranosyl]purine diacetate

: 233756-59-7
5-({9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-methyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 1) t-butyl nitrite, 2) poly<4-vinylpyridinium poly(hydrogen fluoride)> / 1) toluene, 2) toluene

2: 35 percent / 1) Et₂NiPr / dimethylformamide / 80 °C

3: NH₃ / methanol / Ambient temperature

4: Et₃N, DMAP / CH₂Cl₂

With dmap; tert.-butylnitrite; N,N-diethyl-N-isopropylamine; poly<4-vinylpyridinium poly(hydrogen fluoride)>; ammonia; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(99)00857-6

Reference yield:

: 169049-77-8
3',5'-O-diacetyl-2'-deoxy-2-fluoro-O₆-[2-(4-nitrophenyl)ethyl]inosine

: 233756-59-7
5-({9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-methyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / 1) Et₂NiPr / dimethylformamide / 80 °C

2: NH₃ / methanol / Ambient temperature

3: Et₃N, DMAP / CH₂Cl₂

With dmap; N,N-diethyl-N-isopropylamine; ammonia; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(99)00857-6

Reference yield:

: 233756-57-5
Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-{2-[(2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl)-amino]-6-[2-(4-nitro-phenyl)-ethoxy]-purin-9-yl}-tetrahydro-furan-3-yl ester

: 233756-59-7
5-({9-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-[2-(4-nitro-phenyl)-ethoxy]-9H-purin-2-ylamino}-methyl)-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: NH₃ / methanol / Ambient temperature

2: Et₃N, DMAP / CH₂Cl₂

With dmap; ammonia; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(99)00857-6