(SS,1R,2S,5R)-(-)-1-(2-chlorophenylsulfinyloxy)-2-isopropyl-5-methylcyclohaxane

Base Information

• Chemical Name: (SS,1R,2S,5R)-(-)-1-(2-chlorophenylsulfinyloxy)-2-isopropyl-5-methylcyclohaxane
• CAS No.: 243143-03-5
• Molecular Formula: C₁₆H₂₃ClO₂S
• Molecular Weight: 314.876
• Mol file: 243143-03-5.mol

Synonyms:

Chemical Property of (SS,1R,2S,5R)-(-)-1-(2-chlorophenylsulfinyloxy)-2-isopropyl-5-methylcyclohaxane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (SS,1R,2S,5R)-(-)-1-(2-chlorophenylsulfinyloxy)-2-isopropyl-5-methylcyclohaxane

There total 4 articles about (SS,1R,2S,5R)-(-)-1-(2-chlorophenylsulfinyloxy)-2-isopropyl-5-methylcyclohaxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chlorobenzenesulphinic acid (45750-59-2) → (SS,1R,2S,5R)-(-)-1-(2-chlorophenylsulfinyloxy)-2-isopropyl-5-methylcyclohaxane (243143-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / Ambient temperature

2: pyridine / diethyl ether / 1 h / Ambient temperature

With pyridine; thionyl chloride; In diethyl ether; benzene;

DOI:10.1016/S0957-4166(99)00078-6

Reference yield:

o-chloroaniline (95-51-2) → (SS,1R,2S,5R)-(-)-1-(2-chlorophenylsulfinyloxy)-2-isopropyl-5-methylcyclohaxane (243143-03-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) aq. NaNO₂, H₂SO₄, 2.) Cu, SO₂ / 1.) 0 deg C, 2.) -25 deg C, 1 h

2: SOCl₂ / benzene / Ambient temperature

3: pyridine / diethyl ether / 1 h / Ambient temperature

With pyridine; thionyl chloride; sulfuric acid; sulfur dioxide; copper; sodium nitrite; In diethyl ether; benzene;

DOI:10.1016/S0957-4166(99)00078-6

Reference yield:

(-)-menthol (2216-51-5) + 2-chlorobenzenesulfinyl chloride → (SS,1R,2S,5R)-(-)-1-(2-chlorophenylsulfinyloxy)-2-isopropyl-5-methylcyclohaxane (243143-03-5)

Guidance literature:

With pyridine; In diethyl ether; for 1h; Yield given; Ambient temperature;

DOI:10.1016/S0957-4166(99)00078-6

upstream raw materials:

(-)-menthol

2-chlorophenylsulfonyl chloride

2-chlorobenzenesulphinic acid

o-chloroaniline

Downstream raw materials:

(R)-(+)-2-chlorophenyl methyl sulfoxide

(R)-(+)-2-chlorophenyl 4-methylphenyl sulfoxide