2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate

Base Information

Chemical Name:2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate
CAS No.:374067-99-9
Molecular Formula:C₃₁H₃₁Br₂N₅O₇S
Molecular Weight:777.49
Hs Code.:

2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate

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Chemical Property of 2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate

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Technology Process of 2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate

There total 11 articles about 2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 374067-98-8
2-(4-(N-acetyl-N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate

: 374067-99-9
2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 2h; Heating;
DOI:10.1021/jm000538f

Reference yield:

: 2901-13-5
ethyl 2-methyl-2-phenylpropionate

: 374067-99-9
2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate

Guidance literature:: Multi-step reaction with 11 steps

1: ClSO₃H / CH₂Cl₂ / 22 h / 20 °C

2: 1.56 g / aq. NH₄OH / ethyl acetate / 2 h / 20 °C

3: 94 percent / aq. NaOH / methanol / 22 h / 20 °C

4: 98 percent / NaBH₄; BF₃*Et₂O / tetrahydrofuran / 3 h / 20 °C

5: 71 percent / K₂CO₃ / dimethylsulfoxide / 1.5 h / 80 °C

6: 83 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 20 °C

7: NaH / 48 h / 110 °C

8: 395 mg / NaH / N,N-dimethyl-acetamide; tetrahydrofuran / 3 h / 20 °C

9: 87 percent / p-TsOH*H₂O / methanol; tetrahydrofuran / 16 h / 20 °C

10: 88 percent / pyridine / 18 h / 20 °C

11: NBS; AIBN / CCl₄ / 2 h / Heating

With pyridine; chlorosulfonic acid; ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); boron trifluoride diethyl etherate; (1S)-10-camphorsulfonic acid; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm000538f

Reference yield:

: 374067-96-6
4-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide

: 374067-99-9
2-(4-(N-acetyl-N-(5-((4-bromomethyl)phenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)sulfamoyl)phenyl)-2-methylpropyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1: 71 percent / K₂CO₃ / dimethylsulfoxide / 1.5 h / 80 °C

2: 83 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 20 °C

3: NaH / 48 h / 110 °C

4: 395 mg / NaH / N,N-dimethyl-acetamide; tetrahydrofuran / 3 h / 20 °C

5: 87 percent / p-TsOH*H₂O / methanol; tetrahydrofuran / 16 h / 20 °C

6: 88 percent / pyridine / 18 h / 20 °C

7: NBS; AIBN / CCl₄ / 2 h / Heating

With pyridine; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); (1S)-10-camphorsulfonic acid; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1021/jm000538f