(4S,5R)-3-((2R,3R)-2-Azido-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-3-((2R,3R)-2-Azido-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one
CAS No.:145929-84-6
Molecular Formula:C₄₁H₄₇ClN₄O₇Si
Molecular Weight:771.385
Hs Code.:

(4S,5R)-3-((2R,3R)-2-Azido-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

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Chemical Property of (4S,5R)-3-((2R,3R)-2-Azido-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

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Technology Process of (4S,5R)-3-((2R,3R)-2-Azido-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

There total 10 articles about (4S,5R)-3-((2R,3R)-2-Azido-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145929-83-5
(4S,5R)-3-((2S,3R)-2-Bromo-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

: 145929-84-6
(4S,5R)-3-((2R,3R)-2-Azido-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1039/c39920001693

Reference yield:

: 621-59-0
isovanillin

: 145929-84-6
(4S,5R)-3-((2R,3R)-2-Azido-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 63 percent / CuO, K₂CO₃, pyridine / 12 h / Heating

2: 80 percent / Cl₂, SnCl₄ / CH₂Cl₂ / Ambient temperature

3: NaBH₄ / ethanol / 0 °C

4: imidazole / dimethylformamide / Ambient temperature

5: LiAlH₄ / tetrahydrofuran / 0 °C

6: MnO₂ / benzene / Heating

7: 83 percent / diethyl ether / -78 - 0 °C

8: NaN₃ / dimethylformamide / Ambient temperature

With pyridine; 1H-imidazole; manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; chlorine; tin(IV) chloride; potassium carbonate; copper(II) oxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1039/c39920001693

Reference yield:

: 619-42-1
4-methoxycarbonylphenyl bromide

: 145929-84-6
(4S,5R)-3-((2R,3R)-2-Azido-3-{3-chloro-4-[5-(di-tert-butyl-phenyl-silanyloxymethyl)-2-methoxy-phenoxy]-phenyl}-3-hydroxy-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1: 63 percent / CuO, K₂CO₃, pyridine / 12 h / Heating

2: 80 percent / Cl₂, SnCl₄ / CH₂Cl₂ / Ambient temperature

3: NaBH₄ / ethanol / 0 °C

4: imidazole / dimethylformamide / Ambient temperature

5: LiAlH₄ / tetrahydrofuran / 0 °C

6: MnO₂ / benzene / Heating

7: 83 percent / diethyl ether / -78 - 0 °C

8: NaN₃ / dimethylformamide / Ambient temperature

With pyridine; 1H-imidazole; manganese(IV) oxide; sodium tetrahydroborate; lithium aluminium tetrahydride; sodium azide; chlorine; tin(IV) chloride; potassium carbonate; copper(II) oxide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1039/c39920001693