4-Chloro-1-(3-Methyl-2-thienyl)-1-butanone

Base Information

• Chemical Name: 4-Chloro-1-(3-Methyl-2-thienyl)-1-butanone
• CAS No.: 157925-24-1
• Molecular Formula: C₉H₁₁ClOS
• Molecular Weight: 202.705
• Mol file: 157925-24-1.mol

Synonyms:

Chemical Property of 4-Chloro-1-(3-Methyl-2-thienyl)-1-butanone

Chemical Property:

Purity/Quality:

4-Chloro-1-(3-methyl-2-thienyl)-1-butanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 4-Chloro-1-(3-methyl-2-thienyl)-1-butanone is used in the synthesis of intermediates of GABA uptake inhibitors.

Technology Process of 4-Chloro-1-(3-Methyl-2-thienyl)-1-butanone

There total 2 articles about 4-Chloro-1-(3-Methyl-2-thienyl)-1-butanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-3-methylthiophene (14282-76-9) → 4-chloro-β-methyl-butyrothienone (157925-24-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Mg / tetrahydrofuran / 1 h / Heating

2: 2.) H₃O(+)

With oxonium; magnesium; In tetrahydrofuran;

DOI:10.1016/S0040-4020(01)85345-X

Reference yield:

4-Chlorobutyronitrile (628-20-6) + 3-methyl-2-thienyl magnesium bromide (95184-07-9) → 4-chloro-β-methyl-butyrothienone (157925-24-1)

Guidance literature:

With oxonium; Yield given. Multistep reaction;

DOI:10.1016/S0040-4020(01)85345-X

upstream raw materials:

4-Chlorobutyronitrile

3-methyl-2-thienyl magnesium bromide

2-bromo-3-methylthiophene

Refernces