2-(Tosylmethyl)tetrahydrofuran

Base Information

• Chemical Name: 2-(Tosylmethyl)tetrahydrofuran
• CAS No.: 129532-93-0
• Molecular Formula: C12H16O3S
• Molecular Weight: 240.323
• DSSTox Substance ID: DTXSID80577821
• Mol file: 129532-93-0.mol

Synonyms:2-(tosylmethyl)tetrahydrofuran;129532-93-0;4-methylphenyl tetrahydro-2-furanylmethyl sulfone;DTXSID80577821;AKOS008507896;2-(p-tolylsulfonyl-methyl)-tetrahydro-furan;2-[(4-Methylbenzene-1-sulfonyl)methyl]oxolane

Chemical Property of 2-(Tosylmethyl)tetrahydrofuran

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 240.08201554
• Heavy Atom Count: 16
• Complexity: 310

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)CC2CCCO2

Technology Process of 2-(Tosylmethyl)tetrahydrofuran

There total 10 articles about 2-(Tosylmethyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

toluene-4-sulfonic acid pent-4-enyl ester (19300-54-0) → 2-(tosylmethyl)tetrahydrofuran (129532-93-0)

Guidance literature:

With dibenzoyl peroxide; In tetrachloromethane; at 80 - 90 ℃; for 16h; also alkenyl thiotosylate;

DOI:10.1016/0040-4039(91)80246-3

Reference yield: 95.0%

2-((p-tolylthio)methyl)tetrahydrofuran (69645-02-9) → 2-(tosylmethyl)tetrahydrofuran (129532-93-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; at 20 ℃; for 3h;

DOI:10.1021/acs.orglett.6b00272

Reference yield:

4-Iodo-5-(toluene-4-sulfonyl)-pentan-1-ol (141246-58-4) → 2-(tosylmethyl)tetrahydrofuran (129532-93-0)

Guidance literature:

With potassium carbonate; In methanol; for 5h; Yield given; Heating;

DOI:10.1016/S0040-4039(00)91731-3

upstream raw materials:

toluene-4-sulfonic acid pent-4-enyl ester

4-Iodo-5-(toluene-4-sulfonyl)-pentan-1-ol

tert-Butyl-[4-iodo-5-(toluene-4-sulfonyl)-pentyloxy]-dimethyl-silane

n-Pent-4-enyl alcohol