2-(2,2-difluoroethenyl)benzenecarboxylic acid

Base Information

• Chemical Name: 2-(2,2-difluoroethenyl)benzenecarboxylic acid
• CAS No.: 126441-25-6
• Molecular Formula: C₉H₆F₂O₂
• Molecular Weight: 184.142
• Mol file: 126441-25-6.mol

Synonyms:

Chemical Property of 2-(2,2-difluoroethenyl)benzenecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,2-difluoroethenyl)benzenecarboxylic acid

There total 1 articles about 2-(2,2-difluoroethenyl)benzenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

methyl 2-(2,2-difluorovinyl)benzoate (105074-25-7) → 2-(2,2-difluoroethenyl)benzenecarboxylic acid (126441-25-6)

Guidance literature:

With trimethylsilyl iodide; at 50 ℃; for 1h;

DOI:10.1016/S0022-1139(00)84153-6

Reference yield:

2-(2,2-difluoroethenyl)benzenecarboxylic acid (126441-25-6) → 2-(2,2-Difluoro-vinyl)-benzoyl chloride

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In diethyl ether; for 0.75h; Ambient temperature;

DOI:10.1016/S0022-1139(00)84153-6

Reference yield:

2-(2,2-difluoroethenyl)benzenecarboxylic acid (126441-25-6) → 2-(2,2-difluoroethenyl)benzenecarboxamide

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride, DMF / diethyl ether / 0.75 h / Ambient temperature

2: 76 percent / NH₃ / diethyl ether

With oxalyl dichloride; ammonia; N,N-dimethyl-formamide; In diethyl ether;

DOI:10.1016/S0022-1139(00)84153-6

upstream raw materials:

methyl 2-(2,2-difluorovinyl)benzoate

Downstream raw materials:

N-methyl 2-(2,2-difluoroethenyl)-benzenecarboxamide