(6S,7R)-8-[1-Hydroxy-meth-(E)-ylidene]-9-oxo-6-(3,4,5-trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-naphtho[2,3-b][1,4]dioxine-7-carboxylic acid

Base Information

Chemical Name:(6S,7R)-8-[1-Hydroxy-meth-(E)-ylidene]-9-oxo-6-(3,4,5-trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-naphtho[2,3-b][1,4]dioxine-7-carboxylic acid
CAS No.:126382-32-9
Molecular Formula:C₂₃H₂₂O₉
Molecular Weight:442.422
Hs Code.:

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Chemical Property of (6S,7R)-8-[1-Hydroxy-meth-(E)-ylidene]-9-oxo-6-(3,4,5-trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-naphtho[2,3-b][1,4]dioxine-7-carboxylic acid

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Technology Process of (6S,7R)-8-[1-Hydroxy-meth-(E)-ylidene]-9-oxo-6-(3,4,5-trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-naphtho[2,3-b][1,4]dioxine-7-carboxylic acid

There total 11 articles about (6S,7R)-8-[1-Hydroxy-meth-(E)-ylidene]-9-oxo-6-(3,4,5-trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-naphtho[2,3-b][1,4]dioxine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 126382-28-3
Ethyl 6,7-ethylenedioxy-1,2,3,4-tetrahydro-4-(3',4',5'-trimethoxyphenyl)-1-oxo-3-naphthoate

: 109-94-4
formic acid ethyl ester

: 126382-32-9
(6S,7R)-8-[1-Hydroxy-meth-(E)-ylidene]-9-oxo-6-(3,4,5-trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-naphtho[2,3-b][1,4]dioxine-7-carboxylic acid

: 126382-35-2
(6S,7R)-8-[1-Hydroxy-meth-(E)-ylidene]-9-oxo-6-(3,4,5-trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-naphtho[2,3-b][1,4]dioxine-7-carboxylic acid ethyl ester

Guidance literature:: With sodium hydride; In ethanol; benzene; for 12h; Ambient temperature;

Reference yield:

: 493-09-4
benzo-1,4-dioxane

: 126382-32-9
(6S,7R)-8-[1-Hydroxy-meth-(E)-ylidene]-9-oxo-6-(3,4,5-trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-naphtho[2,3-b][1,4]dioxine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / stannic chloride / CH₂Cl₂ / 24 h / Ambient temperature

2: potassium / 2-methyl-propan-2-ol / 24 h / Heating

3: NaOH / methanol; H₂O

4: 93 percent / 10percent sodium amalgam, 2percent aq. NaOH / Ambient temperature

5: acetyl chloride

6: 64 percent / stannic chloride / nitrobenzene / 1) 2 h, 0 deg C, 2) 10 h, room temperature

7: 81 percent / conc. H₂SO₄ / 6 h / Heating

8: 11 percent / NaH / ethanol; benzene / 12 h / Ambient temperature

With sodium hydroxide; sodium amalgam; potassium; tin(IV) chloride; sodium hydride; acetyl chloride; sulfuric acid; In methanol; ethanol; dichloromethane; water; nitrobenzene; tert-butyl alcohol; benzene;

Reference yield:

: 4521-61-3
3,4,5-Trimethoxybenzoyl chloride

: 126382-32-9
(6S,7R)-8-[1-Hydroxy-meth-(E)-ylidene]-9-oxo-6-(3,4,5-trimethoxy-phenyl)-2,3,6,7,8,9-hexahydro-naphtho[2,3-b][1,4]dioxine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / stannic chloride / CH₂Cl₂ / 24 h / Ambient temperature

2: potassium / 2-methyl-propan-2-ol / 24 h / Heating

3: NaOH / methanol; H₂O

4: 93 percent / 10percent sodium amalgam, 2percent aq. NaOH / Ambient temperature

5: acetyl chloride

6: 64 percent / stannic chloride / nitrobenzene / 1) 2 h, 0 deg C, 2) 10 h, room temperature

7: 81 percent / conc. H₂SO₄ / 6 h / Heating

8: 11 percent / NaH / ethanol; benzene / 12 h / Ambient temperature

With sodium hydroxide; sodium amalgam; potassium; tin(IV) chloride; sodium hydride; acetyl chloride; sulfuric acid; In methanol; ethanol; dichloromethane; water; nitrobenzene; tert-butyl alcohol; benzene;