(R)-2-(3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-methoxy-phosphinoyl}-propionylamino)-propionic acid methyl ester

Base Information

Chemical Name:(R)-2-(3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-methoxy-phosphinoyl}-propionylamino)-propionic acid methyl ester
CAS No.:203806-15-9
Molecular Formula:C₂₉H₃₆N₃O₉P
Molecular Weight:601.593
Hs Code.:

(R)-2-(3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-methoxy-phosphinoyl}-propionylamino)-propionic acid methyl ester

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Chemical Property of (R)-2-(3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-methoxy-phosphinoyl}-propionylamino)-propionic acid methyl ester

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Technology Process of (R)-2-(3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-methoxy-phosphinoyl}-propionylamino)-propionic acid methyl ester

There total 10 articles about (R)-2-(3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-methoxy-phosphinoyl}-propionylamino)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 85-44-9
phthalic anhydride

: 203806-15-9
(R)-2-(3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-methoxy-phosphinoyl}-propionylamino)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / toluene / Heating

2: 1.) Me₂SO, (COCl)2, 2.) Et₃N / 1.) -78 deg C

3: 36 percent / H₃PO₂ / aq. ethanol / 80 °C

4: 85 percent / CF₃COOH / 1 h / Heating

5: 100 percent / aq. NaOH / dioxane / 4 h / 0 °C

6: 0.67 h / 110 °C

7: 1 h / 90 °C

8: diethyl ether / 16 h

With sodium hydroxide; oxalyl dichloride; hypophosphorous acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; diethyl ether; ethanol; toluene;
DOI:10.1039/a704097k

Reference yield:

: 2508-29-4
5-hydroxypentylamine

: 203806-15-9
(R)-2-(3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-methoxy-phosphinoyl}-propionylamino)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 99 percent / toluene / Heating

2: 1.) Me₂SO, (COCl)2, 2.) Et₃N / 1.) -78 deg C

3: 36 percent / H₃PO₂ / aq. ethanol / 80 °C

4: 85 percent / CF₃COOH / 1 h / Heating

5: 100 percent / aq. NaOH / dioxane / 4 h / 0 °C

6: 0.67 h / 110 °C

7: 1 h / 90 °C

8: diethyl ether / 16 h

With sodium hydroxide; oxalyl dichloride; hypophosphorous acid; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; In 1,4-dioxane; diethyl ether; ethanol; toluene;
DOI:10.1039/a704097k

Reference yield:

: 95691-09-1
5-phthalimido-1-pentanal

: 203806-15-9
(R)-2-(3-{[1-Benzyloxycarbonylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pentyl]-methoxy-phosphinoyl}-propionylamino)-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 36 percent / H₃PO₂ / aq. ethanol / 80 °C

2: 85 percent / CF₃COOH / 1 h / Heating

3: 100 percent / aq. NaOH / dioxane / 4 h / 0 °C

4: 0.67 h / 110 °C

5: 1 h / 90 °C

6: diethyl ether / 16 h

With sodium hydroxide; hypophosphorous acid; trifluoroacetic acid; In 1,4-dioxane; diethyl ether; ethanol;
DOI:10.1039/a704097k