Cbz-(Z)-ΔOrn(Cbz)-OH

Base Information

Chemical Name:Cbz-(Z)-ΔOrn(Cbz)-OH
CAS No.:121592-48-1
Molecular Formula:C₂₁H₂₂N₂O₆
Molecular Weight:398.415
Hs Code.:

Synonyms:

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Chemical Property of Cbz-(Z)-ΔOrn(Cbz)-OH

Chemical Property:

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Technology Process of Cbz-(Z)-ΔOrn(Cbz)-OH

There total 11 articles about Cbz-(Z)-ΔOrn(Cbz)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 114684-70-7
Cbz-(Z)-Δ-Orn(Cbz)-OMe

: 121592-48-1,114684-72-9
Cbz-(Z)-ΔOrn(Cbz)-OH

Guidance literature:: With lithium hydroxide; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(00)96397-4

Reference yield:

: 130680-59-0
Cbz-ΔGlu-OMe

: 121592-48-1,114684-72-9
Cbz-(Z)-ΔOrn(Cbz)-OH

Guidance literature:: Multi-step reaction with 7 steps

1: 86 percent / NaBH₄/BF₃*OEt₂ / tetrahydrofuran / 0.05 h / -10 °C

2: 74 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

3: 44 percent / NaN₃, 15-crown-5 / dimethylformamide / 2 h / 50 °C

4: 93 percent / benzene / 4 h / 20 °C

5: H₂O / tetrahydrofuran / 6 h / 20 °C

6: Et₃N / tetrahydrofuran / 3 h / 20 °C

7: 80 percent / LiOH / dioxane / 3 h / 20 °C

With pyridine; lithium hydroxide; sodium tetrahydroborate; sodium azide; 15-crown-5; boron trifluoride diethyl etherate; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; benzene; 1: Reduction / 2: Substitution / 3: Substitution / 4: Substitution / 5: Hydrolysis / 6: Acylation / 7: Hydrolysis;
DOI:10.1055/s-2000-6219

Reference yield:

: 139125-35-2
methyl (Z)-2-(N-Cbz)amino-5-hydroxypent-2-enoate

: 121592-48-1,114684-72-9
Cbz-(Z)-ΔOrn(Cbz)-OH

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / pyridine / CH₂Cl₂ / 6 h / 20 °C

2: 44 percent / NaN₃, 15-crown-5 / dimethylformamide / 2 h / 50 °C

3: 93 percent / benzene / 4 h / 20 °C

4: H₂O / tetrahydrofuran / 6 h / 20 °C

5: Et₃N / tetrahydrofuran / 3 h / 20 °C

6: 80 percent / LiOH / dioxane / 3 h / 20 °C

With pyridine; lithium hydroxide; sodium azide; 15-crown-5; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; benzene; 1: Substitution / 2: Substitution / 3: Substitution / 4: Hydrolysis / 5: Acylation / 6: Hydrolysis;
DOI:10.1055/s-2000-6219