Toluene-4-sulfonic acid (S)-2-[(4S,5S,6R)-6-((S)-2-benzyloxymethoxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (S)-2-[(4S,5S,6R)-6-((S)-2-benzyloxymethoxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester
CAS No.:86534-96-5
Molecular Formula:C₂₈H₄₀O₇S
Molecular Weight:520.687
Hs Code.:

Synonyms:

Suppliers and Price of Toluene-4-sulfonic acid (S)-2-[(4S,5S,6R)-6-((S)-2-benzyloxymethoxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Toluene-4-sulfonic acid (S)-2-[(4S,5S,6R)-6-((S)-2-benzyloxymethoxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Toluene-4-sulfonic acid (S)-2-[(4S,5S,6R)-6-((S)-2-benzyloxymethoxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester

There total 12 articles about Toluene-4-sulfonic acid (S)-2-[(4S,5S,6R)-6-((S)-2-benzyloxymethoxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 86534-96-5
Toluene-4-sulfonic acid (S)-2-[(4S,5S,6R)-6-((S)-2-benzyloxymethoxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: (iC₃H₇)2NC₂H₅ / CH₂Cl₂

2: DIBAL / CH₂Cl₂ / -78 °C

3: 95 percent / PCC, propylene oxide / CH₂Cl₂

4: tetrahydrofuran / 10 h / -100 °C

5: LiAlH₄ / diethyl ether / 0 °C

6: (C₄H₉)4N⁽¹⁺⁾*F(-) / tetrahydrofuran

7: N(C₂H₅)3, p-N(CH₃)2-pyridine / CH₂Cl₂

8: pyridinium tosylate / CH₂Cl₂

With dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; methyloxirane; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)81643-3

Reference yield:

: (2S,3R,4S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2,4-dimethyl-pentanoic acid

: 86534-96-5
Toluene-4-sulfonic acid (S)-2-[(4S,5S,6R)-6-((S)-2-benzyloxymethoxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: diethyl ether

2: (iC₃H₇)2NC₂H₅ / CH₂Cl₂

3: DIBAL / CH₂Cl₂ / -78 °C

4: 95 percent / PCC, propylene oxide / CH₂Cl₂

5: tetrahydrofuran / 10 h / -100 °C

6: LiAlH₄ / diethyl ether / 0 °C

7: (C₄H₉)4N⁽¹⁺⁾*F(-) / tetrahydrofuran

8: N(C₂H₅)3, p-N(CH₃)2-pyridine / CH₂Cl₂

9: pyridinium tosylate / CH₂Cl₂

With dmap; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; methyloxirane; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)81643-3

Reference yield:

: (2S,3R,4R)-3-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-5-oxo-pentanoic acid

: 86534-96-5
Toluene-4-sulfonic acid (S)-2-[(4S,5S,6R)-6-((S)-2-benzyloxymethoxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: NaBH₄ / methanol; CH₂Cl₂ / 4 h / -78 - 20 °C

2: diethyl ether

3: (iC₃H₇)2NC₂H₅ / CH₂Cl₂

4: DIBAL / CH₂Cl₂ / -78 °C

5: 95 percent / PCC, propylene oxide / CH₂Cl₂

6: tetrahydrofuran / 10 h / -100 °C

7: LiAlH₄ / diethyl ether / 0 °C

8: (C₄H₉)4N⁽¹⁺⁾*F(-) / tetrahydrofuran

9: N(C₂H₅)3, p-N(CH₃)2-pyridine / CH₂Cl₂

10: pyridinium tosylate / CH₂Cl₂

With dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; methyloxirane; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(00)81643-3