C₂₀H₂₁NO₅

Base Information

• Chemical Name: C₂₀H₂₁NO₅
• CAS No.: 1173933-72-6
• Molecular Formula: C₂₀H₂₁NO₅
• Molecular Weight: 355.39
• Mol file: 1173933-72-6.mol

Synonyms:

Chemical Property of C₂₀H₂₁NO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₀H₂₁NO₅

There total 4 articles about C₂₀H₂₁NO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C18H17NO5 (1173933-71-5) + dimethyl sulfate (77-78-1) → C20H21NO5 (1173933-72-6)

Guidance literature:

With potassium carbonate; In acetone; for 10h; Reflux;

DOI:10.1016/j.ejmech.2010.11.025

Reference yield:

levodopa (59-92-7,90638-38-3) → C20H21NO5 (1173933-72-6)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / 72 h / 20 °C

2: sodium acetate; acetic acid / 20 h / 20 °C

3: sodium formate; acetic anhydride / 4 h / 20 °C

4: potassium carbonate / acetone / 10 h / Reflux

With thionyl chloride; sodium formate; sodium acetate; acetic anhydride; potassium carbonate; acetic acid; In acetone; 2: |Pictet-Spengler Synthesis;

DOI:10.1016/j.cclet.2013.02.014

Reference yield:

C17H17NO4 (1173933-70-4) → C20H21NO5 (1173933-72-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium formate; acetic anhydride / 4 h / 20 °C

2: potassium carbonate / acetone / 10 h / Reflux

With sodium formate; acetic anhydride; potassium carbonate; In acetone;

DOI:10.1016/j.cclet.2013.02.014

upstream raw materials:

C₁₈H₁₇NO₅

dimethyl sulfate

levodopa

C₁₇H₁₇NO₄

Downstream raw materials:

C₅₂H₇₀N₄O₈

C₅₃H₇₂N₄O₈

C₅₄H₇₄N₄O₈

C₅₅H₇₆N₄O₈

Refernces

• 1、 Xu, Geng,Yan, Zheng,Wang, Nan,Liu, Zhanzhu. "Synthesis and cytotoxicity of cis-dichloroplatinum (II) complexes of (1S,3S)-1,2,3,4-tetrahydroisoquinolines". scheme or table. p. 356 - 363. Retrieved 2011/02/26.