((1R,3S)-3-(((R)-2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)-2,2-dimethylcyclopropyl)diphenylmethanol

Base Information

• Chemical Name: ((1R,3S)-3-(((R)-2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)-2,2-dimethylcyclopropyl)diphenylmethanol
• CAS No.: 1310487-01-4
• Molecular Formula: C₃₀H₄₅NO₂Si
• Molecular Weight: 479.778
• Mol file: 1310487-01-4.mol

Synonyms:

Chemical Property of ((1R,3S)-3-(((R)-2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)-2,2-dimethylcyclopropyl)diphenylmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1R,3S)-3-(((R)-2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)-2,2-dimethylcyclopropyl)diphenylmethanol

There total 5 articles about ((1R,3S)-3-(((R)-2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)-2,2-dimethylcyclopropyl)diphenylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C24H31NO2 (1310487-07-0) + tert-butyldimethylsilyl chloride (18162-48-6) → ((1R,3S)-3-(((R)-2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)-2,2-dimethylcyclopropyl)diphenylmethanol (1310487-01-4)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201100535

Reference yield:

(1R,3S)-methyl 3-(((R)-2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-2,2-dimethyl cyclopropanecarboxylate (1310487-05-8) → ((1R,3S)-3-(((R)-2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)-2,2-dimethylcyclopropyl)diphenylmethanol (1310487-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 48 h / Cooling with ice; Inert atmosphere

2: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.201100535

Reference yield:

methyl (1R,3S)-3-formyl-2,2-dimethylcyclopropanecarboxylate (55701-02-5) → ((1R,3S)-3-(((R)-2-((tert-butyldimethylsilyloxy)methyl)pyrrolidin-1-yl)methyl)-2,2-dimethylcyclopropyl)diphenylmethanol (1310487-01-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; sodium cyanoborohydride / methanol / 16 h / 20 °C / Inert atmosphere

2: tetrahydrofuran / 48 h / Cooling with ice; Inert atmosphere

3: 1H-imidazole / dichloromethane / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sulfuric acid; sodium cyanoborohydride; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1002/chem.201100535

upstream raw materials:

C₂₄H₃₁NO₂

tert-butyldimethylsilyl chloride

(1R,3S)-methyl 3-(((R)-2-(hydroxymethyl)pyrrolidin-1-yl)methyl)-2,2-dimethyl cyclopropanecarboxylate

(1R,3S)-(-)-2,2-Dimethyl-3-formylcyclopropane-1-carboxylic acid