1-Benzyl-4-benzyloxy-3-tert-butoxy-1,5-dihydro-2-pyrrolon

Base Information

Chemical Name:1-Benzyl-4-benzyloxy-3-tert-butoxy-1,5-dihydro-2-pyrrolon
CAS No.:160621-80-7
Molecular Formula:C₂₂H₂₅NO₃
Molecular Weight:351.445
Hs Code.:

Synonyms:

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Chemical Property of 1-Benzyl-4-benzyloxy-3-tert-butoxy-1,5-dihydro-2-pyrrolon

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Technology Process of 1-Benzyl-4-benzyloxy-3-tert-butoxy-1,5-dihydro-2-pyrrolon

There total 1 articles about 1-Benzyl-4-benzyloxy-3-tert-butoxy-1,5-dihydro-2-pyrrolon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 908094-04-2
phenyldiazomethane

: 154669-38-2
1-Benzyl-3-tert-butoxy-1,5-dihydro-4-hydroxy-2-pyrrolon

: 160621-80-7
1-Benzyl-4-benzyloxy-3-tert-butoxy-1,5-dihydro-2-pyrrolon

Guidance literature:: In methanol; hexane; for 0.5h; Ambient temperature;

Reference yield:

: 160621-80-7
1-Benzyl-4-benzyloxy-3-tert-butoxy-1,5-dihydro-2-pyrrolon

: (3R,3aR,6aS)-4-Benzyl-3,6,6a-trihydroxy-hexahydro-furo[3,2-b]pyrrol-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) potassium bis(trimethylsilyl)amide / 1.) CH₂Cl₂, toluene, -78 deg C, 2 h, 2.) CH₂Cl₂, toluene, -100 deg C, 5 min

2: 81 percent / H₂ / Pd(OH)2/C / ethyl acetate / 1.5 h / Ambient temperature

3: 60 percent / water, glacial acetic acid / tetrahydrofuran / 48 h / Ambient temperature

4: 60 percent / trifluoroacetic acid / 0.25 h / Ambient temperature

With water; hydrogen; potassium hexamethylsilazane; acetic acid; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; ethyl acetate;

Reference yield:

: 160621-80-7
1-Benzyl-4-benzyloxy-3-tert-butoxy-1,5-dihydro-2-pyrrolon

: (5R*)-(+/-)-1-Benzyl-5-<(1S*)-1,2-dihydroxyethyl>-1,5-dihydro-3,4-dimetoxy-2-pyrrolon

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) potassium bis(trimethylsilyl)amide / 1.) CH₂Cl₂, toluene, -78 deg C, 2 h, 2.) CH₂Cl₂, toluene, -100 deg C, 5 min

2: 81 percent / H₂ / Pd(OH)2/C / ethyl acetate / 1.5 h / Ambient temperature

3: 60 percent / water, glacial acetic acid / tetrahydrofuran / 48 h / Ambient temperature

4: 60 percent / trifluoroacetic acid / 0.25 h / Ambient temperature

5: 56 percent / methanol; diethyl ether / 0.5 h

With water; hydrogen; potassium hexamethylsilazane; acetic acid; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethyl acetate;