Ethyl 2-(naphthalen-1-yl)quinoline-4-carboxylate

Base Information

• Chemical Name: Ethyl 2-(naphthalen-1-yl)quinoline-4-carboxylate
• CAS No.: 6318-00-9
• Molecular Formula: C₂₂H₁₇NO₂
• Molecular Weight: 327.382
• NSC Number: 25686
• DSSTox Substance ID: DTXSID60282385
• Wikidata: Q82016642
• Mol file: 6318-00-9.mol

Synonyms:ethyl 2-(naphthalen-1-yl)quinoline-4-carboxylate;NSC25686;DTXSID60282385;NSC-25686;AKOS025139220;ethyl 2-(1-naphthyl)quinoline-4-carboxylate

Chemical Property of Ethyl 2-(naphthalen-1-yl)quinoline-4-carboxylate

Chemical Property:

• Vapor Pressure: 3.76E-10mmHg at 25°C
• Boiling Point: 500.5°C at 760 mmHg
• Flash Point: 256.5°C
• Density: 1.209g/cm³
• XLogP3: 5.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 327.125928785
• Heavy Atom Count: 25
• Complexity: 465

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC(=NC2=CC=CC=C21)C3=CC=CC4=CC=CC=C43

Technology Process of Ethyl 2-(naphthalen-1-yl)quinoline-4-carboxylate

There total 4 articles about Ethyl 2-(naphthalen-1-yl)quinoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-oxo-propionic acid ethyl ester (617-35-6) + 1-naphthaldehyde (66-77-3) + aniline (62-53-3) → 4-ethoxycarbonyl-2-naphthylquinoline (6318-00-9)

Guidance literature:

With zirconocene dichloride; 1,2,4-benzene tricarboxylic acid; copper(II) oxide; In water; isopropyl alcohol; at 60 ℃; for 2h; Green chemistry;

DOI:10.1039/c7ra00870h

Reference yield: 63.0%

ethanol (64-17-5) + 2-(naphthalen-1-yl)quinoline-4-carboxylic acid (6265-23-2) → 4-ethoxycarbonyl-2-naphthylquinoline (6318-00-9)

Guidance literature:

With sulfuric acid; for 16h; Reflux; Schlenk technique;

DOI:10.1002/chem.202004146

Reference yield:

2-(naphthalen-1-yl)quinoline-4-carboxylic acid (6265-23-2) → 4-ethoxycarbonyl-2-naphthylquinoline (6318-00-9)

Guidance literature:

With sulfuric acid;

DOI:10.1021/ja01216a087

upstream raw materials:

2-(naphthalen-1-yl)quinoline-4-carboxylic acid

2-oxo-propionic acid ethyl ester

1-naphthaldehyde

aniline