[3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile

Base Information

• Chemical Name: [3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile
• CAS No.: 863225-74-5
• Molecular Formula: C₃₆H₃₂ClF₃N₂O₃Si
• Molecular Weight: 661.195
• Mol file: 863225-74-5.mol

Synonyms:

Chemical Property of [3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile

There total 1 articles about [3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one (863225-72-3) + iodoacetonitrile (624-75-9) → (2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenoxy)-acetonitrile (863225-73-4) + [3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile (863225-74-5) + [3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-cyanomethoxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile

Guidance literature:

With potassium carbonate; In acetone; Heating;

DOI:10.1016/j.bmcl.2005.06.056

Reference yield:

[3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile (863225-74-5) → acetic acid 2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-1-carbamoylmethyl-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / 1,2-dichloro-ethane

2: Na₂O₂; H₂O₂ / methanol

With sodium peroxide; dihydrogen peroxide; triethylamine; In methanol; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2005.06.056

Reference yield:

[3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-2-oxo-6-trifluoromethyl-2H-quinolin-1-yl]-acetonitrile (863225-74-5) → acetic acid 2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-1-carbamimidoylmethyl-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / 1,2-dichloro-ethane

2: NaOMe; NH₄Cl / methanol

With sodium methylate; ammonium chloride; triethylamine; In methanol; 1,2-dichloro-ethane;

DOI:10.1016/j.bmcl.2005.06.056

upstream raw materials:

3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-4-(5-chloro-2-hydroxy-phenyl)-6-trifluoromethyl-1H-quinolin-2-one

iodoacetonitrile

Downstream raw materials:

acetic acid 2-{3-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-1-cyanomethyl-2-oxo-6-trifluoromethyl-1,2-dihydro-quinolin-4-yl}-4-chloro-phenyl ester