Technology Process of all-syn-1,2,3,4-tetrafluorocyclohexane
There total 9 articles about all-syn-1,2,3,4-tetrafluorocyclohexane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen; (2-(2,6-diisopropylphenyl)-3,3-dimethyl-2-azaspiro[4.5]decan-1-ylidene)(cyclooctadienyl)rhodium(I) chloride;
In
hexane;
at 25 ℃;
for 24h;
under 37503.8 Torr;
Molecular sieve;
Autoclave;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: triphenyl phosphite; ozone / dichloromethane / 2 h / -78 - -25 °C / Inert atmosphere
2: tris(triphenylphosphine)ruthenium(II) chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
3: triethylamine tris(hydrogen fluoride) / 3 h / 90 °C / Inert atmosphere
4: pyridine; thionyl chloride / dichloromethane / 14 h / 0 - 20 °C / Inert atmosphere
5: sodium periodate; rhodium(III) chloride hydrate / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere
6: triethylamine tris(hydrogen fluoride) / 20 h / 120 °C / Inert atmosphere
7: pyridine / 2 h / 20 °C / Inert atmosphere
8: triethylamine tris(hydrogen fluoride) / 16 h / 120 °C / Inert atmosphere
With
pyridine; triphenyl phosphite; sodium periodate; tris(triphenylphosphine)ruthenium(II) chloride; thionyl chloride; rhodium(III) chloride hydrate; ozone; triethylamine tris(hydrogen fluoride);
In
dichloromethane; acetonitrile;
DOI:10.1039/c1cc13016a
- Guidance literature:
-
With
triethylamine tris(hydrogen fluoride);
at 120 ℃;
for 16h;
Inert atmosphere;
DOI:10.1039/c1cc13016a
