3,6-difluorocyclohexane-1,2-diol

Base Information

• Chemical Name: 3,6-difluorocyclohexane-1,2-diol
• CAS No.: 1319205-46-3
• Molecular Formula: C₆H₁₀F₂O₂
• Molecular Weight: 152.141

Synonyms:

Chemical Property of 3,6-difluorocyclohexane-1,2-diol

Chemical Property:

Purity/Quality:

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Technology Process of 3,6-difluorocyclohexane-1,2-diol

There total 3 articles about 3,6-difluorocyclohexane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclohexa-1,3-diene (1165952-91-9) → 3,6-difluorocyclohexane-1,2-diol (1319205-46-3)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenyl phosphite; ozone / dichloromethane / 2 h / -78 - -25 °C / Inert atmosphere

2: tris(triphenylphosphine)ruthenium(II) chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

3: triethylamine tris(hydrogen fluoride) / 3 h / 90 °C / Inert atmosphere

With triphenyl phosphite; tris(triphenylphosphine)ruthenium(II) chloride; ozone; triethylamine tris(hydrogen fluoride); In dichloromethane;

DOI:10.1039/c1cc13016a

Reference yield:

(1R,1S)-2,3-dioxabicyclo[2.2.2]oct-5-ene (6671-70-1) → 3,6-difluorocyclohexane-1,2-diol (1319205-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tris(triphenylphosphine)ruthenium(II) chloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: triethylamine tris(hydrogen fluoride) / 3 h / 90 °C / Inert atmosphere

With tris(triphenylphosphine)ruthenium(II) chloride; triethylamine tris(hydrogen fluoride); In dichloromethane;

DOI:10.1039/c1cc13016a

Reference yield:

syn-1,2;3,4-diepoxycyclohexane (74643-89-3) → 3,6-difluorocyclohexane-1,2-diol (1319205-46-3)

Guidance literature:

With triethylamine tris(hydrogen fluoride); at 90 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c1cc13016a

upstream raw materials:

(1R,1S)-2,3-dioxabicyclo[2.2.2]oct-5-ene

syn-1,2;3,4-diepoxycyclohexane

cyclohexa-1,3-diene

Downstream raw materials:

all-syn-1,2,3,4-tetrafluorocyclohexane

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