10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane

Base Information

Chemical Name:10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane
CAS No.:236427-89-7
Molecular Formula:C₅₁H₈₂O₁₀Si₂
Molecular Weight:911.377
Hs Code.:

10-[7-benzyloxymethyl-2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane

Synonyms:

Suppliers and Price of 10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane

There total 26 articles about 10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 236427-87-5
(2R,5S,6S,8R,10S)-10-((1S,2S,3S,5S,7R)-7-Benzyloxymethyl-2-hydroxy-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecan-5-ol

: 10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane

: 236427-89-7
10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; for 20h; Ambient temperature;
DOI:10.1055/s-1999-2689

Reference yield:

: (2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecan-5-ol

: 236427-89-7
10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane

Guidance literature:: Multi-step reaction with 9 steps

1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

2: 81 percent / H₂ / Raney Ni (W₂) / ethanol / 4 h / Ambient temperature

3: 100 percent / Dess-Martin periodinane / CH₂Cl₂ / 5 h / Ambient temperature

4: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1.5 h

5: Dess-Martin periodinane / CH₂Cl₂ / 3 h / Ambient temperature

6: SmI₂ / tetrahydrofuran; methanol / 1 h / -95 - -80 °C

7: Zn-Cu couple, NH₄Cl / methanol / 0.17 h / Ambient temperature

8: 60 percent / HF, H₂O / acetonitrile; tetrahydrofuran / 11 h / Ambient temperature

9: 49 percent / 2,6-lutidine / CH₂Cl₂ / 20 h / Ambient temperature

With 2,6-dimethylpyridine; n-butyllithium; samarium diiodide; hydrogen fluoride; water; hydrogen; copper; ammonium chloride; Dess-Martin periodane; zinc; Raney Ni (W₂); In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1055/s-1999-2689

Reference yield:

: 236427-81-9
{(2R,5S,6S,8S,10S)-10-(2-Benzyloxy-ethyl)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadec-5-yloxy}-triethyl-silane

: 236427-89-7
10-[7-benzyloxymethyl-2-(tert-butyl-dimethyl-silanyloxy)-3-methyl-6,8-dioxa-bicyclo[3.2.1]oct-5-ylmethyl]-5-(tert-butyl-dimethyl-silanyloxy)-2-[2-(4-methoxy-benzyloxy)-ethyl]-5-methyl-1,7,9-trioxa-dispiro[5.1.5.2]pentadecane

Guidance literature:: Multi-step reaction with 8 steps

1: 81 percent / H₂ / Raney Ni (W₂) / ethanol / 4 h / Ambient temperature

2: 100 percent / Dess-Martin periodinane / CH₂Cl₂ / 5 h / Ambient temperature

3: 1.) BuLi / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 1.5 h

4: Dess-Martin periodinane / CH₂Cl₂ / 3 h / Ambient temperature

5: SmI₂ / tetrahydrofuran; methanol / 1 h / -95 - -80 °C

6: Zn-Cu couple, NH₄Cl / methanol / 0.17 h / Ambient temperature

7: 60 percent / HF, H₂O / acetonitrile; tetrahydrofuran / 11 h / Ambient temperature

8: 49 percent / 2,6-lutidine / CH₂Cl₂ / 20 h / Ambient temperature

With 2,6-dimethylpyridine; n-butyllithium; samarium diiodide; hydrogen fluoride; water; hydrogen; copper; ammonium chloride; Dess-Martin periodane; zinc; Raney Ni (W₂); In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1055/s-1999-2689